Molecular Mechanisms of Cardiacvoltage-Gated Na+ Channel Regulation by Acidic pH
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.591
Abstract: Background: During ischemic heart disease, pH drops from 7.4 to 6.0 within 10 minutes of onset, severely affecting ion channel gating. The cardiac sodium channel (Nav1.5) is particularly susceptible to this abrupt pH change, and… read more here.
Keywords: mechanisms cardiacvoltage; channel regulation; cardiacvoltage gated; molecular mechanisms ... See more keywords
PEP-PREDNa+: A web server for prediction of highly specific peptides targeting voltage-gated Na+ channels using machine learning techniques.
Sign Up to like & getrecommendations! Published in 2022 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2022.105414
Abstract: Voltage-gated sodium channel activity has long been associated with several diseases including epilepsy, chronic pain, cardiovascular diseases, cancers, immune system, neuromuscular and respiratory disorders. The strong participation of these channels in the development of diseases… read more here.
Keywords: pep predna; prediction; highly specific; voltage gated ... See more keywords
Structural basis for C-type inactivation in a Shaker family voltage-gated K+ channel
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm8804
Abstract: C-type inactivation is a process by which ion flux through a voltage-gated K+ (Kv) channel is regulated at the selectivity filter. While prior studies have indicated that C-type inactivation involves structural changes at the selectivity… read more here.
Keywords: voltage gated; gated channel; type inactivation; selectivity filter ... See more keywords
The mono-ADP-ribosyltransferase ARTD10 regulates the voltage-gated K+ channel Kv1.1 through protein kinase C delta
Sign Up to like & getrecommendations! Published in 2020 at "BMC Biology"
DOI: 10.1186/s12915-020-00878-1
Abstract: Background ADP-ribosylation is a ubiquitous post-translational modification that involves both mono- and poly-ADP-ribosylation. ARTD10, also known as PARP10, mediates mono-ADP-ribosylation (MARylation) of substrate proteins. A previous screen identified protein kinase C delta (PKCδ) as a… read more here.
Keywords: kinase delta; artd10; protein kinase; mono adp ... See more keywords
The Sweetpotato Voltage-Gated K+ Channel β Subunit, KIbB1, Positively Regulates Low-K+ and High-Salinity Tolerance by Maintaining Ion Homeostasis
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13061100
Abstract: Voltage-gated K+ channel β subunits act as a structural component of Kin channels in different species. The β subunits are not essential to the channel activity but confer different properties through binding the T1 domain… read more here.
Keywords: voltage gated; gated channel; high salinity; channel subunit ... See more keywords
Molecular, Cellular and Functional Changes in the Retinas of Young Adult Mice Lacking the Voltage-Gated K+ Channel Subunits Kv8.2 and K2.1
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22094877
Abstract: Cone Dystrophy with Supernormal Rod Response (CDSRR) is a rare autosomal recessive disorder leading to severe visual impairment in humans, but little is known about its unique pathophysiology. We have previously shown that CDSRR is… read more here.
Keywords: voltage; young adult; mice; gated channel ... See more keywords
Inhibitory Effects of Nobiletin on Voltage-Gated Na+ Channel in Rat Ventricular Myocytes Based on Electrophysiological Analysis and Molecular Docking Method
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232315175
Abstract: Nobiletin (NOB) has attracted much attention owing to its outstanding bioactivities. This study aimed to investigate its anti-arrhythmic effect through electrophysiological and molecular docking studies. We assessed the anti-arrhythmic effects of NOB using aconitine-induced ventricular… read more here.
Keywords: molecular docking; voltage gated; gated channel; voltage ... See more keywords
Complex interactions between p.His558Arg and linked variants in the sodium voltage-gated channel alpha subunit 5 (NaV1.5)
Sign Up to like & getrecommendations! Published in 2022 at "PeerJ"
DOI: 10.7717/peerj.13913
Abstract: Common genetic polymorphisms may modify the phenotypic outcome when co-occurring with a disease-causing variant, and therefore understanding their modulating role in health and disease is of great importance. The polymorphic p.His558Arg variant of the sodium… read more here.
Keywords: voltage gated; sodium voltage; gated channel; alpha subunit ... See more keywords