A Shared Mechanism for the Folding of Voltage-Gated K+ Channels.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00068
Abstract: In this study, we probe the folding of KvAP, a voltage-gated K+ (Kv) channel. The KvAP channel, though of archaebacterial origin, is structurally and functionally similar to eukaryotic Kv channels. An advantage of the KvAP… read more here.
Keywords: kvap channel; gated channels; mechanism; voltage gated ... See more keywords
Evolution and Structural Characteristics of Plant Voltage-Gated K+ Channels
Sign Up to like & getrecommendations! Published in 2018 at "Plant Cell"
DOI: 10.1105/tpc.18.00523
Abstract: Plant voltage-gated K+ channels have been referred to as “plant Shakers” in reference to animal Shaker channels, the first K+ channels identified. Recent advances in our knowledge of K+ channel evolution and structure have significantly… read more here.
Keywords: plant voltage; plant; cyclic nucleotide; gated channels ... See more keywords
A computational model for how the fast afterhyperpolarization paradoxically increases gain in regularly firing neurons.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of neurophysiology"
DOI: 10.1152/jn.00385.2017
Abstract: The gain of a neuron, the number and frequency of action potentials triggered in response to a given amount of depolarizing injection, is an important behavior underlying a neuron's function. Variations in action potential waveform… read more here.
Keywords: computational model; afterhyperpolarization; gated channels; ahp ... See more keywords
Stretch-activated current in human atrial myocytes and Na+ current and mechano-gated channels’ current in myofibroblasts alter myocyte mechanical behavior: a computational study
Sign Up to like & getrecommendations! Published in 2019 at "BioMedical Engineering OnLine"
DOI: 10.1186/s12938-019-0723-5
Abstract: BackgroundThe activation of stretch-activated channels (SACs) in cardiac myocytes, which changes the phases of action potential repolarization, is proven to be highly efficient for the conversion of atrial fibrillation. The expression of Na+ current in… read more here.
Keywords: stretch activated; gated channels; mechano gated; activated current ... See more keywords
The in vitro anticancer effects of FS48 from salivary glands of Xenopsylla cheopis on NCI-H460 cells via its blockage of voltage-gated K+ channels
Sign Up to like & getrecommendations! Published in 2023 at "Acta Pharmaceutica"
DOI: 10.2478/acph-2023-0010
Abstract: Abstract Voltage-gated K+ (Kv) channels play a role in the cellular processes of various cancer cells, including lung cancer cells. We previously identified and reported a salivary protein from the Xenopsylla cheopis, FS48, which exhibited… read more here.
Keywords: voltage gated; nci h460; gated channels; effects fs48 ... See more keywords
A Meta-Analysis Study to Infer Voltage-Gated K+ Channels Prognostic Value in Different Cancer Types
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12030573
Abstract: Potassium channels are often highly expressed in cancer cells with respect to healthy ones, as they provide proliferative advantages through modulating membrane potential, calcium homeostasis, and various signaling pathways. Among potassium channels, Shaker type voltage-gated… read more here.
Keywords: voltage gated; different cancer; gated channels; cancer types ... See more keywords