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Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1739
Abstract: Pentameric ligand-gated ion channels (pLGICs) control synaptic neurotransmission in higher eukaryotes via an allosteric mechanism, where agonist binding in the extra-cellular domain triggers the opening of an ion-conducting pore in the transmembrane domain. Here we…
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Keywords:
gated ion;
pentameric ligand;
ion;
ligand gated ... See more keywords
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Published in 2020 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2020.05.030
Abstract: Pulsed electric fields are increasingly used in medicine to transiently increase the cell membrane permeability via electroporation to deliver therapeutic molecules into the cell. One type of event that contributes to this increase in membrane…
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Keywords:
pores voltage;
pulsed electric;
electric fields;
ion channels ... See more keywords
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Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.167095
Abstract: Allosteric signaling underlies the function of many biomolecules, including membrane proteins such as ion channels. Experimental methods have enabled specific quantitative insights into the coupling between the voltage sensing domain and the pore gate of…
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Keywords:
ion channels;
gated ion;
coupling voltage;
ion ... See more keywords
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Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.08.007
Abstract: Pentameric ligand-gated ion channels (pLGICs) are the targets of several clinical and endogenous allosteric modulators including anesthetics and neurosteroids. Molecular mechanisms underlying allosteric drug modulation are poorly understood. Here, we constructed a chimeric pLGIC by…
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Keywords:
modulation;
gated ion;
pentameric ligand;
ligand gated ... See more keywords
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Published in 2019 at "Progress in Retinal and Eye Research"
DOI: 10.1016/j.preteyeres.2019.05.001
Abstract: In this review, we summarize studies investigating the types and distribution of voltage- and calcium-gated ion channels in the different classes of retinal neurons: rods, cones, horizontal cells, bipolar cells, amacrine cells, interplexiform cells, and…
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Keywords:
voltage calcium;
ion channels;
gated ion;
ion ... See more keywords
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Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01304
Abstract: Ion channels have been characterized as promising drug targets for treatment of numerous human diseases. Functions of ion channels can be fine-tuned by allosteric modulators, which interact with channels and modulate their activities by binding…
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Keywords:
gated voltage;
ion channels;
gated ion;
ion ... See more keywords
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Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b05058
Abstract: Coating the inner wall of a quartz nanopipet with a thin layer of carbon yields a nanopore with tunable surface charge and chemical state for resistive-pulse and rectification sensing. Herein we report the experimental study…
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Keywords:
carbon;
ion transport;
gated ion;
electron transfer ... See more keywords
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Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-27974-w
Abstract: Photoactivatable drugs targeting ligand-gated ion channels open up new opportunities for light-guided therapeutic interventions. Photoactivable toxins targeting ion channels have the potential to control excitable cell activities with low invasiveness and high spatiotemporal precision. As…
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Keywords:
ion channels;
spatiotemporal control;
gated ion;
voltage gated ... See more keywords
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Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1809650115
Abstract: Significance Molecular mechanisms of general anesthetic modulation in pentameric ligand-gated ion channels remain controversial. Here we present molecular simulations and functional data that reveal correlations between dynamic differences in a membrane-accessible cavity and dramatic anesthetic…
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Keywords:
gated ion;
cavity;
ion;
ligand gated ... See more keywords
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Published in 2019 at "Toxin Reviews"
DOI: 10.1080/15569543.2019.1579230
Abstract: Abstract Ligand-gated ion channels (LGIC) are membranous proteins that allow ionic flow across plasma membrane upon ligand binding. The channels are implicated in many physiological and pathological processes. Understanding the functionality of LGIC leads to…
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Keywords:
ion channels;
gated ion;
spider toxins;
ligand gated ... See more keywords
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Published in 2017 at "Channels"
DOI: 10.1080/19336950.2016.1213929
Abstract: ABSTRACT Two-pore channels (TPC1-3) comprise a subfamily of the eukaryotic voltage-gated ion channels (VGICs) superfamily that are mainly expressed in acidic stores in plants and animals. TPCS are widespread across the animal kingdom, with primates,…
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Keywords:
ion channels;
pore channels;
gated ion;
two pore ... See more keywords