Antagonism of the ATP-gated P2X7 receptor: a potential therapeutic strategy for cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Purinergic signalling"
DOI: 10.1007/s11302-021-09776-9
Abstract: The P2X receptor 7 (P2X7R) is a plasma membrane receptor sensing extracellular ATP associated with a wide variety of cellular functions. It is most commonly expressed on immune cells and is highly upregulated in a… read more here.
Keywords: gated p2x7; cancer; potential therapeutic; receptor ... See more keywords
Increased expression of the ATP-gated P2X7 receptor reduces responsiveness to anti-convulsants during status epilepticus in mice.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of pharmacology"
DOI: 10.1111/bph.15785
Abstract: BACKGROUND AND PURPOSE Refractory status epilepticus is a clinical emergency associated with high mortality and morbidity. Increasing evidence suggests neuroinflammation contributes to the development of drug-refractoriness during status epilepticus. The aim of the present study… read more here.
Keywords: gated p2x7; atp gated; p2x7r; status ... See more keywords