Extracellular S100B inhibits A‐type voltage‐gated potassium currents and increases L‐type voltage‐gated calcium channel activity in dopaminergic neurons
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24254
Abstract: Parkinson's disease (PD) is associated with an increase in secreted S100B within the midbrain and cerebrospinal fluid. In addition, S100B overexpression in mice accelerates the loss of substantia nigra pars compacta dopaminergic (DA) neurons, suggesting… read more here.
Keywords: type voltage; gated potassium; extracellular s100b; voltage gated ... See more keywords
Identification and Pharmacological Characterization of the Voltage-gated Potassium Channel Shab in Diamondback moth, Plutella xylostella.
Sign Up to like & getrecommendations! Published in 2022 at "Pest management science"
DOI: 10.1002/ps.7300
Abstract: BACKGROUND Voltage-gated potassium channel Kv2 is the primarily delayed rectifier in insect nerves and muscles involved in several crucial biological processes, including action potential regulation, photoreceptor performance, and larval locomotor. It is a potential molecular… read more here.
Keywords: gated potassium; voltage gated; plutella xylostella; potassium channel ... See more keywords
Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel KV1.3: Role of Conformational Dynamics
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c01237
Abstract: Peptide toxins that adopt the ShK fold can inhibit the voltage-gated potassium channel KV1.3 with IC50 values in the pM range and are therefore potential leads for drugs targeting autoimmune and neuroinflammatory diseases. Nuclear magnetic… read more here.
Keywords: gated potassium; voltage gated; kv1; channel kv1 ... See more keywords
Detection of Voltage-Gated Potassium Channels 1.3 via Immuno-PET Visualizes Rheumatoid Arthritis.
Sign Up to like & getrecommendations! Published in 2025 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.5c00357
Abstract: Rheumatoid arthritis (RA) is a chronic inflammatory condition affecting approximately 1% of the global population, yet current diagnostic tools for early-stage RA lack sensitivity and fail to identify optimal treatment candidates. Voltage-gated potassium channel 1.3… read more here.
Keywords: kv1; gated potassium; voltage gated; rheumatoid arthritis ... See more keywords
Regulation of voltage-gated potassium channels attenuates resistance of side-population cells to gefitinib in the human lung cancer cell line NCI-H460
Sign Up to like & getrecommendations! Published in 2017 at "BMC Pharmacology & Toxicology"
DOI: 10.1186/s40360-017-0118-9
Abstract: BackgroundSide-population (SP) cells that exclude anti-cancer drugs have been found in various tumor cell lines. Moreover, SP cells have a higher proliferative potential and drug resistance than main population cells (Non-SP cells). Also, several ion… read more here.
Keywords: gated potassium; cancer; population cells; cell ... See more keywords
Voltage-gated potassium channels are involved in oxymatrine-regulated islet function in rat islet β cells and INS-1 cells
Sign Up to like & getrecommendations! Published in 2021 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2021.52449.11850
Abstract: Objective(s): Oxymatrine can regulate glucose metabolism. But the underlying mechanisms remain unclear. We investigated the relationship of oxymatrine and voltage-gated potassium (Kv) channel in rat islet β cells and INS-1 cells. Materials and Methods: Insulin… read more here.
Keywords: gated potassium; islet; ins cells; islet cells ... See more keywords
1538-P: KCNQ2/3 Voltage Gated Potassium Channels Regulate the Activity of Intrapancreatic Neurons
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DOI: 10.2337/db24-1538-p
Abstract: Introduction & Objective: Input from the parasympathetic nervous system is necessary to adapt pancreatic islet and acinar function to the internal and behavioral status of an organism. pancreancreatic neurons, which form a vast interconnected ganglionated… read more here.
Keywords: physiology; gated potassium; voltage gated; ca2 ... See more keywords
Therapeutic role of voltage-gated potassium channels in age-related neurodegenerative diseases
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DOI: 10.3389/fncel.2024.1406709
Abstract: Voltage-gated ion channels are essential for membrane potential maintenance, homeostasis, electrical signal production and controlling the Ca2+ flow through the membrane. Among all ion channels, the key regulators of neuronal excitability are the voltage-gated potassium… read more here.
Keywords: voltage gated; gated potassium; neurodegenerative diseases; potassium channels ... See more keywords
The association between gene polymorphisms in voltage-gated potassium channels Kv2.1 and Kv4.2 and susceptibility to autism spectrum disorder
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.994166
Abstract: Background Autism spectrum disorder (ASD) is a heritable form of neurodevelopmental disorder that arises through synaptic dysfunction. Given the involvement of voltage-gated potassium (Kv) channels in the regulation of synaptic plasticity, we aimed to explore… read more here.
Keywords: gated potassium; voltage gated; autism; autism spectrum ... See more keywords