Extracellular S100B inhibits A‐type voltage‐gated potassium currents and increases L‐type voltage‐gated calcium channel activity in dopaminergic neurons
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DOI: 10.1002/glia.24254
Abstract: Parkinson's disease (PD) is associated with an increase in secreted S100B within the midbrain and cerebrospinal fluid. In addition, S100B overexpression in mice accelerates the loss of substantia nigra pars compacta dopaminergic (DA) neurons, suggesting… read more here.
Keywords: type voltage; gated potassium; extracellular s100b; voltage gated ... See more keywords
Identification and Pharmacological Characterization of the Voltage-gated Potassium Channel Shab in Diamondback moth, Plutella xylostella.
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DOI: 10.1002/ps.7300
Abstract: BACKGROUND Voltage-gated potassium channel Kv2 is the primarily delayed rectifier in insect nerves and muscles involved in several crucial biological processes, including action potential regulation, photoreceptor performance, and larval locomotor. It is a potential molecular… read more here.
Keywords: gated potassium; voltage gated; plutella xylostella; potassium channel ... See more keywords
Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel KV1.3: Role of Conformational Dynamics
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DOI: 10.1021/acs.jcim.2c01237
Abstract: Peptide toxins that adopt the ShK fold can inhibit the voltage-gated potassium channel KV1.3 with IC50 values in the pM range and are therefore potential leads for drugs targeting autoimmune and neuroinflammatory diseases. Nuclear magnetic… read more here.
Keywords: gated potassium; voltage gated; kv1; channel kv1 ... See more keywords
Regulation of voltage-gated potassium channels attenuates resistance of side-population cells to gefitinib in the human lung cancer cell line NCI-H460
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DOI: 10.1186/s40360-017-0118-9
Abstract: BackgroundSide-population (SP) cells that exclude anti-cancer drugs have been found in various tumor cell lines. Moreover, SP cells have a higher proliferative potential and drug resistance than main population cells (Non-SP cells). Also, several ion… read more here.
Keywords: gated potassium; cancer; population cells; cell ... See more keywords
Voltage-gated potassium channels are involved in oxymatrine-regulated islet function in rat islet β cells and INS-1 cells
Sign Up to like & getrecommendations! Published in 2021 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2021.52449.11850
Abstract: Objective(s): Oxymatrine can regulate glucose metabolism. But the underlying mechanisms remain unclear. We investigated the relationship of oxymatrine and voltage-gated potassium (Kv) channel in rat islet β cells and INS-1 cells. Materials and Methods: Insulin… read more here.
Keywords: gated potassium; islet; ins cells; islet cells ... See more keywords
The association between gene polymorphisms in voltage-gated potassium channels Kv2.1 and Kv4.2 and susceptibility to autism spectrum disorder
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.994166
Abstract: Background Autism spectrum disorder (ASD) is a heritable form of neurodevelopmental disorder that arises through synaptic dysfunction. Given the involvement of voltage-gated potassium (Kv) channels in the regulation of synaptic plasticity, we aimed to explore… read more here.
Keywords: gated potassium; voltage gated; autism; autism spectrum ... See more keywords