Role of the time dependence of Boltzmann open probability in voltage-gated proton channels.
Sign Up to like & getrecommendations! Published in 2020 at "Bioelectrochemistry"
DOI: 10.1016/j.bioelechem.2020.107520
Abstract: The modeling and simulation of experimental families of current-time (I-t) curves of dimeric voltage-gated proton channels and of proton-conducting voltage sensing domains (VSDs) with a minimum of free parameters requires the movement of protons to… read more here.
Keywords: voltage; time; proton channels; gated proton ... See more keywords
Does Proton Conduction in the Voltage-Gated Proton Channel hHV1 Involve Grotthus Hopping via Acidic Residues?
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.899
Abstract: Does Proton Conduction in the Voltage-Gated Proton Channel hH(V)1 Involve Grotthus Hopping via Acidic Residues? read more here.
Keywords: proton channel; involve grotthus; conduction voltage; proton conduction ... See more keywords
Cholesterol inhibits human voltage-gated proton channel hHv1
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2205420119
Abstract: Significance Our work identified membrane cholesterol as a new inhibitor of human voltage-gated proton channel hHv1. Using single-molecule fluorescence resonance energy transfer (smFRET), we further showed that cholesterol inhibits the hHv1 channel by stabilizing the… read more here.
Keywords: human voltage; voltage gated; proton channel; cholesterol ... See more keywords
Role of voltage-gated proton channel (Hv1) in cancer biology
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1175702
Abstract: The acid-base characteristics of tumor cells and the other elements that compose the tumor microenvironment have been topics of scientific interest in oncological research. There is much evidence confirming that pH conditions are maintained by… read more here.
Keywords: voltage gated; proton channel; biology; gated proton ... See more keywords
Voltage-Gated Proton Channel Hv1 Regulates Neuroinflammation and Dopaminergic Neurodegeneration in Parkinson’s Disease Models
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DOI: 10.3390/antiox12030582
Abstract: Although the precise mechanisms for neurodegeneration in Parkinson’s disease (PD) are unknown, evidence suggests that neuroinflammation is a critical factor in the pathogenic process. Here, we sought to determine whether the voltage-gated proton channel, Hv1… read more here.
Keywords: neurodegeneration parkinson; voltage gated; parkinson disease; neurodegeneration ... See more keywords
Activation-pathway transitions in human voltage-gated proton channels revealed by a non-canonical fluorescent amino acid
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.85836
Abstract: Voltage-dependent gating of the voltage-gated proton channels (HV1) remains poorly understood, partly because of the difficulty of obtaining direct measurements of voltage sensor movement in the form of gating currents. To circumvent this problem, we… read more here.
Keywords: proton channels; voltage gated; voltage; non canonical ... See more keywords