Voltage‐gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13641
Abstract: The voltage‐gated sodium channels (VGSCs) are aberrantly expressed in a variety of tumors and play an important role in tumor growth and metastasis. Here, we show that VGSCs auxiliary β3 subunit, encoded by the SCN3B… read more here.
Keywords: degradation; p53 degradation; p53; gated sodium ... See more keywords
Synthesis and Evaluation of Voltage‐Gated Sodium Channel Blocking Pyrroline Derivatives Endowed with Both Antiarrhythmic and Antioxidant Activities
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DOI: 10.1002/cmdc.202000692
Abstract: Under the hypothesis that cardioprotective agents might benefit from synergism between antiarrhythmic activity and antioxidant properties, a small series of mexiletine analogues were coupled with the 2,2,5,5‐tetramethylpyrroline moiety, known for its antioxidant effect, in order… read more here.
Keywords: sodium channel; pyrroline derivatives; synthesis evaluation; evaluation voltage ... See more keywords
Toxins That Affect Voltage-Gated Sodium Channels.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2017_66
Abstract: Voltage-gated sodium channels (VGSCs) are critical in generation and conduction of electrical signals in multiple excitable tissues. Natural toxins, produced by animal, plant, and microorganisms, target VGSCs through diverse strategies developed over millions of years… read more here.
Keywords: pharmacology; gated sodium; sodium channels; voltage gated ... See more keywords
Reduced cooperativity of voltage-gated sodium channels in the hippocampal interneurons of an aged mouse model of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2017 at "European Biophysics Journal"
DOI: 10.1007/s00249-017-1274-y
Abstract: Beta amyloid (A$$\beta$$β ) associated with Alzheimer’s disease (AD) leads to abnormal behavior in inhibitory neurons, resulting in hyperactive neuronal networks, epileptiform behavior, disrupted gamma rhythms, and aberrant synaptic plasticity. Previously, we used a dual… read more here.
Keywords: apde9 mice; alzheimer disease; ntg mice; mice ... See more keywords
[Pain and analgesia : Mutations of voltage-gated sodium channels].
Sign Up to like & getrecommendations! Published in 2017 at "Schmerz"
DOI: 10.1007/s00482-016-0139-0
Abstract: Voltage-gated sodium channels (Navs) are crucial for the generation and propagation of action potentials in all excitable cells, and therefore for the function of sensory neurons as well. Preclinical research over the past 20 years identified… read more here.
Keywords: function; gated sodium; sodium channels; pain ... See more keywords
State-dependent block of voltage-gated sodium channels by the casein-kinase 1 inhibitor IC261
Sign Up to like & getrecommendations! Published in 2017 at "Investigational New Drugs"
DOI: 10.1007/s10637-017-0429-0
Abstract: SummaryBackground and Purpose IC261 (3-[(2,4,6-trimethoxyphenyl)methylidenyl]-indolin-2-one) has previously been introduced as an isoform specific inhibitor of casein kinase 1 (CK1) causing cell cycle arrest or cell death of established tumor cell lines. However, it is reasonable… read more here.
Keywords: state; ic261; sodium; gated sodium ... See more keywords
Non-extensitivity and criticality of atomic hydropathicity around a voltage-gated sodium channel’s pore: a modeling study
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biological Physics"
DOI: 10.1007/s10867-021-09565-w
Abstract: Voltage-gated sodium channels (NavChs) are pore-forming membrane proteins that regulate the transport of sodium ions through the cell membrane. Understanding the structure and function of NavChs is of major biophysical, as well as clinical, importance… read more here.
Keywords: voltage; channel; non extensitivity; gated sodium ... See more keywords
Voltage-gated Sodium Channels and Blockers: An Overview and Where Will They Go?
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DOI: 10.1007/s11596-019-2117-0
Abstract: Voltage-gated sodium (Nav) channels are critical players in the generation and propagation of action potentials by triggering membrane depolarization. Mutations in Nav channels are associated with a variety of channelopathies, which makes them relevant targets… read more here.
Keywords: channels blockers; nav channels; gated sodium; sodium channels ... See more keywords
Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Special Focus on Nav1.7, Species Differences, and Regulation by Paclitaxel
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DOI: 10.1007/s12264-017-0132-3
Abstract: Abstract Voltage-gated sodium channels (Navs) play an important role in human pain sensation. However, the expression and role of Nav subtypes in native human sensory neurons are unclear. To address this issue, we obtained human… read more here.
Keywords: expression role; expression; role; gated sodium ... See more keywords
[Lidocaine in oncological surgery: the role of blocking in voltage-gated sodium channels. A narrative review].
Sign Up to like & getrecommendations! Published in 2020 at "Revista brasileira de anestesiologia"
DOI: 10.1016/j.bjan.2020.04.018
Abstract: BACKGROUND The current evidence suggests that oncological surgery, which is a therapy used in the treatment of solid tumors, increases the risk of metastasis. In this regard, a wide range of tumor cells express Voltage-Gated… read more here.
Keywords: tumor cells; oncological surgery; gated sodium; sodium channels ... See more keywords
In silico exploration of aryl sulfonamide analogs as voltage-gated sodium channel 1.7 inhibitors by using 3D-QSAR, molecular docking study, and molecular dynamics simulations
Sign Up to like & getrecommendations! Published in 2018 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2018.10.009
Abstract: It has been demonstrated by human genetics that the voltage-gated sodium channel Nav1.7 is currently a promising target for the treatment of pain. In this research, we performed molecular simulation works on a series of… read more here.
Keywords: aryl sulfonamide; sodium channel; inhibitors using; gated sodium ... See more keywords