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   Articles with "gatekeeper" as a keyword



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Engineering Nucleotide Specificity of Succinyl-CoA Synthetase in Blastocystis: The Emerging Role of Gatekeeper Residues

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recommendations! Published in 2017 at "Biochemistry"

DOI: 10.1021/acs.biochem.6b00098

Abstract: Charged, solvent-exposed residues at the entrance to the substrate binding site (gatekeeper residues) produce electrostatic dipole interactions with approaching substrates, and control their access by a novel mechanism called “electrostatic gatekeeper effect”. This proof-of-concept study… read more here.

Keywords: gatekeeper residues; binding site; nucleotide specificity; gatekeeper ... See more keywords
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Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4.

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recommendations! Published in 2022 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.2c00096

Abstract: Aberrant FGF19/FGFR4 signaling has been shown to be an oncogenic driver of growth and survival in human hepatocellular carcinoma (HCC) with several pan-FGFR inhibitors and FGFR4-selective inhibitors currently being evaluated in the clinic. However, FGFR4… read more here.

Keywords: fgfr4; inhibitors wild; type gatekeeper; gatekeeper ... See more keywords
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Feasibility of brief online gatekeeper training for Japanese university students: A randomized controlled trial

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recommendations! Published in 2022 at "Death Studies"

DOI: 10.1080/07481187.2022.2101076

Abstract: Abstract Gatekeeper training for university students is a promising suicide prevention approach. However, there is a lack of comparative studies with control groups and the effectiveness of online gatekeeper training programs is unclear. We investigated… read more here.

Keywords: university students; online gatekeeper; gatekeeper; gatekeeper training ... See more keywords
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Assessment, accountability, and access: Constrained skill mastery as instructional gatekeeper

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recommendations! Published in 2021 at "Journal of Early Childhood Literacy"

DOI: 10.1177/14687984211042056

Abstract: The nature of the literacy assessments valued in the persistent accountability climate within U.S. public education, coupled with an increasingly polarized discourse around what counts as the science of reading (SOR), have resulted in instructional… read more here.

Keywords: constrained skill; skill mastery; accountability access; assessment accountability ... See more keywords
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The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity

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recommendations! Published in 2019 at "Frontiers in Microbiology"

DOI: 10.3389/fmicb.2019.01923

Abstract: Maintenance of Borrelia burgdorferi within its enzootic cycle requires a complex regulatory pathway involving the alternative σ factors RpoN and RpoS and two ancillary trans-acting factors, BosR and Rrp2. Activation of this pathway occurs within… read more here.

Keywords: rpos; persistence; gatekeeper; burgdorferi ... See more keywords