Gatekeeper mutations activate FGF receptor tyrosine kinases by destabilizing the autoinhibited state.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2213090120
Abstract: Many types of human cancers are being treated with small molecule ATP-competitive inhibitors targeting the kinase domain of receptor tyrosine kinases. Despite initial successful remission, long-term treatment almost inevitably leads to the emergence of drug… read more here.
Keywords: tyrosine; gatekeeper mutations; tyrosine kinases; receptor tyrosine ... See more keywords