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Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.6b00098
Abstract: Charged, solvent-exposed residues at the entrance to the substrate binding site (gatekeeper residues) produce electrostatic dipole interactions with approaching substrates, and control their access by a novel mechanism called “electrostatic gatekeeper effect”. This proof-of-concept study…
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Keywords:
gatekeeper residues;
binding site;
nucleotide specificity;
gatekeeper ... See more keywords