The Fast Component of hERG Gating Charge: An Interaction between D411 in the S1 and S4 Residues.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.09.004
Abstract: Kv11.1 (hERG) is a voltage-gated potassium channel that shows very slow ionic current activation kinetics, and an unusual underlying biphasic gating charge movement with fast and slow components that differ greatly in time course. The… read more here.
Keywords: gating charge; herg; charge; activation ... See more keywords
Independent movement of the voltage sensors in KV2.1/KV6.4 heterotetramers
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep41646
Abstract: Heterotetramer voltage-gated K+ (KV) channels KV2.1/KV6.4 display a gating charge-voltage (QV) distribution composed by two separate components. We use state dependent chemical accessibility to cysteines substituted in either KV2.1 or KV6.4 to assess the voltage… read more here.
Keywords: kv2 kv6; voltage; gating charge; voltage sensors ... See more keywords