A gating mechanism of K2P channels by their selectivity filter
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjac018
Abstract: Cellular excitability is determined by the flowof different ions across the cellmembrane, which is in turn controlled by the opening and closing of ion-permeable pores, the ion channels (Hille, 2001). For instance, in neurons, the… read more here.
Keywords: k2p; mechanism k2p; gating mechanism; membrane potential ... See more keywords
A loosened gating mechanism of RIG-I leads to autoimmune disorders
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac361
Abstract: Abstract DDX58 encodes RIG-I, a cytosolic RNA sensor that ensures immune surveillance of nonself RNAs. Individuals with RIG-IE510V and RIG-IQ517H mutations have increased susceptibility to Singleton-Merten syndrome (SMS) defects, resulting in tissue-specific (mild) and classic… read more here.
Keywords: loosened gating; rna proofreading; gating mechanism; rna ... See more keywords
Significance of solute specificity, expression, and gating mechanism of tonoplast intrinsic protein during development and stress response in plants.
Sign Up to like & getrecommendations! Published in 2021 at "Physiologia plantarum"
DOI: 10.1111/ppl.13386
Abstract: Tonoplast intrinsic proteins (TIPs), belonging to the aquaporin (AQP) family, are transmembrane channels located mostly at the tonoplast of plant cells. The TIPs are known to transport water and many other small solutes such as… read more here.
Keywords: seed; solute specificity; gating mechanism; expression ... See more keywords
Gating Mechanism of the Voltage-Gated Proton Channel Studied by Molecular Dynamics Simulations
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27072277
Abstract: The voltage-gated proton channel Hv1 has important roles in proton extrusion, pH homeostasis, sperm motility, and cancer progression. The Hv1 channel has also been found to be highly expressed in cell lines and tissue samples… read more here.
Keywords: proton channel; gating mechanism; voltage gated; hv1 ... See more keywords