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Gating movements and ion permeation in HCN4 pacemaker channels

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1 Published in 2021 at "Molecular Cell"

DOI: 10.1016/j.molcel.2021.05.033

Abstract: Summary The HCN1–4 channel family is responsible for the hyperpolarization-activated cation current If/Ih that controls automaticity in cardiac and neuronal pacemaker cells. We present cryoelectron microscopy (cryo-EM) structures of HCN4 in the presence or absence… read more here.

Keywords: gating movements; movements ion; pacemaker; permeation ... See more keywords