Mutations at the M2 and M3 Transmembrane Helices of the GABAARs α1 and β2 Subunits Affect Primarily Late Gating Transitions Including Opening/Closing and Desensitization
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DOI: 10.1021/acschemneuro.1c00151
Abstract: GABA type A receptors (GABAARs) belong to the pentameric ligand-gated ion channel (pLGIC) family and play a crucial role in mediating inhibition in the adult mammalian brain. Recently, a major progress in determining the static… read more here.
Keywords: transmembrane; opening closing; late gating; gating transitions ... See more keywords
Simulating PIP2-Induced Gating Transitions in Kir6.2 Channels
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.711975
Abstract: ATP-sensitive potassium (KATP) channels consist of an inwardly rectifying K+ channel (Kir6.2) pore, to which four ATP-sensitive sulfonylurea receptor (SUR) domains are attached, thereby coupling K+ permeation directly to the metabolic state of the cell.… read more here.
Keywords: simulating pip2; induced gating; pip2; pip2 induced ... See more keywords