Impact of oral gavage technique of drug-containing microcontainers on the gastrointestinal transit and absorption in rats.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2022.121630
Abstract: Oral gavage is the most common way to administer drug formulations orally to rats. Yet, the technique applied and its influence on gastrointestinal (GI) transit receive little attention. This study aims to investigate the impact… read more here.
Keywords: drug; gavage; gastrointestinal transit; oral gavage ... See more keywords
Delivery method matters: omega-3 supplementation by restricted feeding period and oral gavage has a distinct impact on corticosterone secretion and anxious behavior in adolescent rats
Sign Up to like & getrecommendations! Published in 2020 at "Nutritional Neuroscience"
DOI: 10.1080/1028415x.2020.1733813
Abstract: ABSTRACT Objectives: Oral gavage and time-restricted feeding are common delivery methods for dietary supplementation to rodents. However, the stress associated with selected feeding regimens could represent a confounding variable. In rodents, the adolescence period is… read more here.
Keywords: oral gavage; restricted feeding; anxiety; supplementation ... See more keywords
An oral gavage of lysine elicited early satiation while gavages of lysine, leucine, or isoleucine prolonged satiety in pigs
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Animal Science"
DOI: 10.1093/jas/skac361
Abstract: Abstract Excess dietary amino acids (AA) may negatively affect feed intake in pigs. Previous results showed that Lys, Leu, Ile, Phe, and Glu significantly increased gut peptide secretion (i.e., cholecystokinin, glucagon-like peptide 1). However, the… read more here.
Keywords: leu ile; feed intake; gavage; duration ... See more keywords
Differential anxiety-like responses in NOD/ShiLtJ and C57BL/6J mice following experimental autoimmune encephalomyelitis induction and oral gavage
Sign Up to like & getrecommendations! Published in 2018 at "Laboratory Animals"
DOI: 10.1177/0023677218756156
Abstract: Oral gavage is commonly used in pre-clinical drug evaluation, but is potentially aversive and may induce behavioral effects independent of compounds under investigation. This study examined the combined effects of repeated oral gavage and disease… read more here.
Keywords: oral gavage; anxiety like; gavage; mice ... See more keywords
A new method to replace oral gavage for the study of Cryptosporidium infection in mice
Sign Up to like & getrecommendations! Published in 2025 at "Laboratory Animals"
DOI: 10.1177/00236772251318406
Abstract: Oral gavage is a widely used method to infect mice with Cryptosporidium parvum (CP), the most common animal model of infection. Cryptosporidium spp. are worldwide distributed, gastrointestinal parasites that mainly cause diarrhea in humans and… read more here.
Keywords: mice; method; cryptosporidium; infection ... See more keywords
Effects of 0.5% and 2.0% Sodium Lauryl Sulfate in Male CD-1 Mice From a 3-Month Oral Gavage Toxicity Study
Sign Up to like & getrecommendations! Published in 2021 at "Toxicologic Pathology"
DOI: 10.1177/01926233211004873
Abstract: The tolerability of single daily gavage doses of 0.5% or 2.0% (wt/vol) sodium lauryl sulfate (SLS) in 11- to 12-week-old male CD-1 mice was evaluated in a study of 3 months in duration. Live-phase, gross… read more here.
Keywords: lauryl sulfate; male mice; sodium lauryl; gavage ... See more keywords
Institutional protocols for the oral administration (gavage) of chemicals and microscopic microbial communities to mice: Analytical consensus
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Biology and Medicine"
DOI: 10.1177/1535370219838203
Abstract: Although there are numerous Institutional Animal Care and Use Committee (IACUC) protocols aimed at standardizing the oral administration (gavage) of liquid chemicals to laboratory rodents, there is ample variability across protocols, and there are no… read more here.
Keywords: communities mice; consensus; gavage; oral administration ... See more keywords
Gut Akkermansia Muciniphila Ameliorates HIV-1 gp120-Induced Neuronal Pyroptosis By Regulating Kyna Level in Brain Via Blood-Brain Barrier
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-198584
Abstract: Backgrounds: HIV-1 gp120 is a critical virulence factor implicated in HIV-associated neurocognitive disorders (HAND), causing significant neuronal damage. Our previous research has demonstrated elevated transcription of pyroptosis-related genes and increased expression of gasdermin D (GSDMD)… read more here.
Keywords: hiv gp120; mice; brain; pyroptosis ... See more keywords
Stable engraftment of human microbiota into mice with a single oral gavage following antibiotic conditioning
Sign Up to like & getrecommendations! Published in 2017 at "Microbiome"
DOI: 10.1186/s40168-017-0306-2
Abstract: BackgroundHuman microbiota-associated (HMA) animal models relying on germ-free recipient mice are being used to study the relationship between intestinal microbiota and human disease. However, transfer of microbiota into germ-free animals also triggers global developmental changes… read more here.
Keywords: microbiota; antibiotic conditioning; gavage; germ free ... See more keywords
Method for detecting hemodynamic alterations following a single gavage in rats
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Animals"
DOI: 10.1538/expanim.20-0200
Abstract: It is known that administering a gavage to rodents evokes a cardiac reflex, due to gastrointestinal stimulation. Consequently, it is difficult to evaluate changes in hemodynamics after a single oral dose of a pungent or… read more here.
Keywords: gastric tube; condition; gavage; hemodynamic alterations ... See more keywords
The Influence of EGCG on the Pharmacokinetics and Pharmacodynamics of Bisoprolol and a New Method for Simultaneous Determination of EGCG and Bisoprolol in Rat Plasma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.907986
Abstract: Background and Aim Research has shown that green tea catechins may influence the activity of drug metabolizing enzymes and drug transporters. We examined whether epigallocatechin-3-gallate (EGCG) affected the pharmacokinetics and pharmacodynamics of bisoprolol in rats.… read more here.
Keywords: egcg; pharmacokinetics pharmacodynamics; gavage; egcg bisoprolol ... See more keywords