Knockdown of IGF2BP3 inhibits the tumorigenesis of gallbladder cancer and modifies tumor microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.22000
Abstract: Gallbladder cancer (GBC) ranks seventh among the gastrointestinal cancers. Messenger RNAs (mRNAs) could regulate the progression of GBC. For the purpose of exploring the targets for GBC treatment, RNA sequencing was used to identify the… read more here.
Keywords: cell; knockdown igf2bp3; gbc; gbc cells ... See more keywords
Oxymatrine induces apoptosis and inhibits invasion in Gallbladder carcinoma via PTEN/PI3K/AKT pathway
Sign Up to like & getrecommendations! Published in 2017 at "Cytotechnology"
DOI: 10.1007/s10616-017-0153-9
Abstract: Oxymatrine extracted from Sophora flavescens Ait as a natural polyphenolic phytochemical has been demonstrated to exhibit anti-tumor effects on various cancers, including Gallbladder carcinoma (GBC). However, its underlying mechanisms of function are largely unknown in… read more here.
Keywords: gbc cells; akt; pi3k akt; gallbladder carcinoma ... See more keywords
CCL18 secreted from M2 macrophages promotes migration and invasion via the PI3K/Akt pathway in gallbladder cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Oncology"
DOI: 10.1007/s13402-018-0410-8
Abstract: PurposeThe presence of M2 macrophages within primary tumors has been correlated with a poor prognosis for many types of cancer. However, little is known about the role of M2 macrophages in gallbladder cancer (GBC).MethodsThe number… read more here.
Keywords: invasion; pi3k akt; gbc; gallbladder cancer ... See more keywords
Long non-coding RNA SSTR5-AS1 facilitates gemcitabine resistance via stabilizing NONO in gallbladder carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.10.104
Abstract: Gallbladder carcinoma (GBC) is the most aggressive carcinoma of the biliary tract, effective chemotherapy was critical for the patients with unresectable GBC. However, chemotherapy resistance is still problematic for clinicians. Here, we identified a specific… read more here.
Keywords: gbc; sstr5 as1; sstr5; gemcitabine resistance ... See more keywords
The microRNA cluster miR-214/miR-3120 prevents tumor cell switching from an epithelial to a mesenchymal-like phenotype and inhibits autophagy in gallbladder cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2020.109887
Abstract: Tumor cells switch from an epithelial to a mesenchymal-like phenotype, which represents a key hallmark of human cancer metastasis, including gallbladder cancer (GBC). A large set of microRNAs (miRNAs/miRs) have been studied to elucidate their… read more here.
Keywords: gbc cells; 214 3120; epithelial mesenchymal; gbc ... See more keywords
Phosphorylation at Ser10 triggered p27 degradation and promoted gallbladder carcinoma cell migration and invasion by regulating stathmin1 under glucose deficiency.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.109923
Abstract: Gallbladder carcinoma (GBC) is a considerable challenge because of its high metastatic potential. The tumor microenvironment is characterized by nutrient starvation, which promotes tumor metastasis. Stathmin1, an important microtubuleregulating protein, is overexpressed and promotes metastasis… read more here.
Keywords: degradation; cell migration; gbc; deficiency ... See more keywords
Screening and identification of haptoglobin showing its important role in pathophysiological process of gallbladder carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Gene"
DOI: 10.1016/j.gene.2021.145429
Abstract: Gallbladder cancer (GBC) with poor prognosis has been a major cause of cancer-related deaths worldwide. In this study, we aimed to screen and identify crucial genes in GBC through integrative analysis of multiple datasets and… read more here.
Keywords: role pathophysiological; pathophysiological process; gallbladder; gbc ... See more keywords
Imaging and Screening of Cancer of the Gallbladder and Bile Ducts.
Sign Up to like & getrecommendations! Published in 2017 at "Radiologic clinics of North America"
DOI: 10.1016/j.rcl.2017.06.005
Abstract: Biliary cancers include gallbladder cancer (GBC) and cholangiocarcinoma (CCA). GBC may appear as a mass replacing the gallbladder, thickened gallbladder wall, or polypoid lesion in the gallbladder. Gallbladder polyps with low risk of GBC (eg,… read more here.
Keywords: gallbladder; cca; gbc; screening cancer ... See more keywords
OLFM4 depletion sensitizes gallbladder cancer cells to cisplatin through the ARL6IP1/caspase-3 axis.
Sign Up to like & getrecommendations! Published in 2021 at "Translational oncology"
DOI: 10.1016/j.tranon.2021.101331
Abstract: BACKGROUND Gallbladder cancer (GBC) is a highly lethal malignancy that carries an extremely poor prognosis due to its chemoresistant nature. Cisplatin (CDDP) is a first-line chemotherapeutic for GBC; however, patients experienced no benefit when treated… read more here.
Keywords: gbc; olfm4 depletion; expression; gallbladder cancer ... See more keywords
Genetic association of MMP14 promoter variants and their functional significance in gallbladder cancer pathogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of human genetics"
DOI: 10.1038/s10038-021-00917-x
Abstract: Gallbladder cancer (GBC) is relatively rare but shows high frequency in certain geographical regions and ethnic groups, which include Northern and Eastern states of India. Previous studies in India have indicated the possible role of… read more here.
Keywords: mmp14 promoter; pathogenesis; expression; gbc ... See more keywords
High expression of PSMC2 promotes gallbladder cancer through regulation of GNG4 and predicts poor prognosis
Sign Up to like & getrecommendations! Published in 2021 at "Oncogenesis"
DOI: 10.1038/s41389-021-00330-1
Abstract: Gallbladder cancer (GBC) is a common malignant tumor of the biliary tract, which accounts for 80–95% of biliary tumors worldwide, and is the leading cause of biliary malignant tumor-related death. This study identified PSMC2 as… read more here.
Keywords: prognosis; expression; gbc; gallbladder cancer ... See more keywords