A three‐microRNA signature identifies two subtypes of glioblastoma patients with different clinical outcomes
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12047
Abstract: Glioblastoma multiforme (GBM) is the most common and malignant primary brain tumor in adults, characterized by aggressive growth, limited response to therapy, and inexorable recurrence. Because of the extremely unfavorable prognosis of GBM, it is… read more here.
Keywords: microrna signature; identifies two; gbm; signature identifies ... See more keywords
The sex‐dependent role of the androgen receptor in glioblastoma: results of molecular analyses
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13262
Abstract: We sought to analyse the androgen receptor (AR) in glioblastoma (GBM) due to the location of the AR gene on chromosome X, often reported with shorter survival and higher prevalence of GBM among males. Copy… read more here.
Keywords: sex dependent; androgen receptor; expression; receptor glioblastoma ... See more keywords
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Oncology"
DOI: 10.1002/1878-0261.70005
Abstract: Glioblastoma (GBM) is the most aggressive and lethal type of glioma, characterized by aberrant expression of noncoding RNAs including circular RNAs (circRNAs). CircRNAs may impact cellular processes by interacting with other molecules—like RNA‐binding proteins (RBPs).… read more here.
Keywords: wide analysis; transcriptome wide; gbm; rbp ... See more keywords
Glioblastoma in natalizumab‐treated multiple sclerosis patients
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.428
Abstract: We present two natalizumab‐treated multiple sclerosis patients who developed glioblastoma multiforme (GBM) with variable outcomes. One patient had an isocitrate dehydrogenase (IDH)‐wildtype GBM with aggressive behavior, who declined treatment and died 13 weeks after symptoms… read more here.
Keywords: natalizumab treated; gbm; multiple sclerosis; sclerosis patients ... See more keywords
Assembled Embedded 3D Hydrogel System for Asynchronous Drug Delivery to Inhibit Postoperative Recurrence of Malignant Glioma and Promote Neurological Recovery
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202401383
Abstract: Surgical resection of glioblastoma multiforme (GBM) often results in tumor recurrence and mild neurologic deficits. Here, a 3D asynchronous drug delivery system is innovatively developed to address the dual challenges of GBM recurrence and postoperative… read more here.
Keywords: system; drug delivery; delivery; gbm ... See more keywords
Organic Small Molecule Contrast Agent for Targeted Photoacoustic Imaging of Patient‐Derived Brain Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201640
Abstract: Traditional glioblastoma (GBM) cell lines do not maintain the heterogeneity of the original tumor, cell interactions, and therapy response, thus limiting their investigation in GBM theranostics. Herein, a kind of GBM tumor‐targeting nanoparticles (NPs) TCFNP@iRGD… read more here.
Keywords: contrast agent; patient derived; gbm;
Dynamically Crosslinked Poly(ethylene‐glycol) Hydrogels Reveal a Critical Role of Viscoelasticity in Modulating Glioblastoma Fates and Drug Responses in 3D
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202147
Abstract: Glioblastoma multiforme (GBM) is the most prevalent and aggressive brain tumor in adults. Hydrogels have been employed as 3D in vitro culture models to elucidate how matrix cues such as stiffness and degradation drive GBM… read more here.
Keywords: viscoelasticity; drug responses; gbm; drug ... See more keywords
Regulation of Protein Conformation Enables Cell‐Selective Targeting of Virus‐Mimicking Nanoparticles for siRNA Therapy of Glioblastoma
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials"
DOI: 10.1002/adma.202401640
Abstract: Orthotopic glioblastoma (GBM) has an aggressive growth pattern and complex pathogenesis, becoming one of the most common and deadly tumors of the central nervous system (CNS). The emergence of RNA therapies offers promise for the… read more here.
Keywords: virus mimicking; cell selective; selective targeting; gbm ... See more keywords
Preventing Glioblastoma Relapse by Igniting Innate Immunity through Mitochondrial Stress in the Surgical Cavity.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced materials"
DOI: 10.1002/adma.202511351
Abstract: Innate immunity is crucial in orchestrating the brain immune response, however, glioblastoma multiforme (GBM) has evolved sophisticated mechanisms to evade innate immune surveillance, posing significant challenges for current immunotherapies. Here, a therapeutic strategy is reported… read more here.
Keywords: innate immunity; mitochondrial stress; stress; gbm ... See more keywords
Synchronous Disintegration of Ferroptosis Defense Axis via Engineered Exosome‐Conjugated Magnetic Nanoparticles for Glioblastoma Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105451
Abstract: Glioblastoma (GBM) is one of the most fatal central nervous system tumors and lacks effective or sufficient therapies. Ferroptosis is a newly discovered method of programmed cell death and opens a new direction for GBM… read more here.
Keywords: defense axis; magnetic nanoparticles; gbm; disintegration ... See more keywords
Histone H3K9 Lactylation Confers Temozolomide Resistance in Glioblastoma via LUC7L2‐Mediated MLH1 Intron Retention
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202309290
Abstract: Temozolomide (TMZ) resistance remains the major obstacle in the treatment of glioblastoma (GBM). Lactylation is a novel post‐translational modification that is involved in various tumors. However, whether lactylation plays a role in GBM TMZ resistance… read more here.
Keywords: resistance; histone h3k9; lactylation; gbm ... See more keywords