miR-1268a regulates ABCC1 expression to mediate temozolomide resistance in glioblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-018-2835-3
Abstract: IntroductionTemozolomide (TMZ) is the preferred chemotherapeutic drug approved for the Glioblastoma multiforme (GBM) treatment. However, resistance to TMZ is the most intractable challenge for treatment of GBM. Screening of miRNAs is becoming a novel strategy… read more here.
Keywords: treatment; gbm cells; tmz; resistance ... See more keywords
Influence of NSAIDs and methotrexate on CD73 expression and glioma cell growth.
Sign Up to like & getrecommendations! Published in 2021 at "Purinergic signalling"
DOI: 10.1007/s11302-021-09775-w
Abstract: Glioblastoma (GBM) is the most malignant and deadly brain tumor. GBM cells overexpress the CD73 enzyme, which controls the level of extracellular adenosine, an immunosuppressive molecule. Studies have shown that some nonsteroidal anti-inflammatory drugs (NSAIDs)… read more here.
Keywords: nsaids methotrexate; cd73 expression; expression; gbm cells ... See more keywords
Human bone marrow-derived mesenchymal stem cell-secreted exosomes overexpressing microRNA-34a ameliorate glioblastoma development via down-regulating MYCN
Sign Up to like & getrecommendations! Published in 2019 at "Cellular Oncology"
DOI: 10.1007/s13402-019-00461-z
Abstract: Exosomes play important roles in intercellular communication through signaling pathways affecting tumor microenvironment modulation and tumor proliferation, including those in glioblastoma (GBM). As yet, however, limited studies have been conducted on the inhibitory effect of… read more here.
Keywords: gbm; mir 34a; gbm cells; hbmsc ... See more keywords
Pragmatic recruitment of memantine as the capping group for the design of HDAC inhibitors: A preliminary attempt to unravel the enigma of glioblastoma.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113338
Abstract: Hurdled and marred by the notorious nature of glioblastomas (GBM) in terms of resistance to therapy and limited drug delivery into the brain, the anti-GBM drug pipeline is required to be loaded with mechanistically diverse… read more here.
Keywords: gbm; group; hdac inhibitors; gbm cells ... See more keywords
Pediatric glioblastoma cells inhibit neurogenesis and promote astrogenesis, phenotypic transformation and migration of human neural progenitor cells within cocultures
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.11.013
Abstract: Abstract Neural progenitor cell (NPC) fate is influenced by a variety of biological cues elicited from the surrounding microenvironment and recent studies suggest their possible role in pediatric glioblastoma multiforme (GBM) development. Since a few… read more here.
Keywords: neural progenitor; gbm; gbm cells; migration ... See more keywords
The transcript ENST00000444125 of lncRNA LINC01503 promotes cancer stem cell properties of glioblastoma cells via reducing FBXW1 mediated GLI2 degradation.
Sign Up to like & getrecommendations! Published in 2022 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2022.113009
Abstract: LINC010503 is a novel oncogenic lncRNA in multiple cancers. In this study, we further explored the expression of LINC010503 transcripts and their regulations on the glioblastoma (GBM) stem cell (GSC) properties. LINC01503 transcription patterns in… read more here.
Keywords: gli2; cells via; transcript; cell ... See more keywords
ODZ1 allows glioblastoma to sustain invasiveness through a Myc-dependent transcriptional upregulation of RhoA
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.341
Abstract: Long-term survival remains low for most patients with glioblastoma (GBM), which reveals the need for markers of disease outcome and novel therapeutic targets. We describe that ODZ1 (also known as TENM1), a type II transmembrane… read more here.
Keywords: rhoa; odz1; gbm cells; odz1 allows ... See more keywords
Osimertinib successfully combats EGFR-negative glioblastoma cells by inhibiting the MAPK pathway
Sign Up to like & getrecommendations! Published in 2020 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-020-0418-2
Abstract: Glioblastoma (GBM) patients have extremely poor prognoses, and currently no effective treatment available including surgery, radiation, and chemotherapy. MAPK-interacting kinases (MNK1/2) as the downstream of the MAPK-signaling pathway regulate protein synthesis in normal and tumor… read more here.
Keywords: glioblastoma; gbm; gbm cells; pathway ... See more keywords
Cell penetrating peptide decorated magnetic porous silicon nanorods for glioblastoma therapy and imaging
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra00508e
Abstract: Glioblastoma multiforme (GBM) is the most malignant primary brain tumor of the central nervous system. Despite advances in therapy, it remains largely untreatable, in part due to the low permeability of chemotherapeutic drugs across the… read more here.
Keywords: porous silicon; peptide; gbm cells; silicon nanorods ... See more keywords
Paradol Induces Cell Cycle Arrest and Apoptosis in Glioblastoma Cells
Sign Up to like & getrecommendations! Published in 2022 at "Nutrition and Cancer"
DOI: 10.1080/01635581.2022.2028866
Abstract: Abstract Despite being the most common primary malignant tumor of the central nervous system, the prognosis of glioblastoma (GBM) is still remarkably poor. Paradol is a flavor phenolic constituent found in pepper and ginger, with… read more here.
Keywords: apoptosis; arrest; cycle arrest; cell cycle ... See more keywords
Preclinical study of novel tetracyclic small molecule, CC12, for brain cancer
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz243.034
Abstract: Abstract Background The development of a novel therapy for malignant glioma is a vigorous area in both chemistry and cancer research. Previously, we reported that the small molecule naphtho [2, 3-f] quinoxaline-7, 12-dione (CC12) effectively… read more here.
Keywords: gbm; small molecule; gbm cells; cc12 ... See more keywords