Detection of gene mutations and gene-gene fusions in circulating cell-free DNA of glioblastoma patients: an avenue for clinically relevant diagnostic analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13157
Abstract: Glioblastoma (GBM) is the most common type of glioma and is uniformly fatal. Currently, tumour heterogeneity and mutation acquisition are major impedances for tailoring personalized therapy. We collected blood and tumour tissue samples from 25… read more here.
Keywords: dna; mutations gene; gene fusions; gbm patients ... See more keywords
A pilot study: Metabolic profiling of plasma and saliva samples from newly diagnosed glioblastoma patients.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.5857
Abstract: BACKGROUND Despite aggressive treatment, more than 90% of glioblastoma (GBM) patients experience recurrences. GBM response to therapy is currently assessed by imaging techniques and tissue biopsy. However, difficulties with these methods may cause misinterpretation of… read more here.
Keywords: glioblastoma; plasma; study metabolic; metabolic profiling ... See more keywords
Proteome profiling of salivary small extracellular vesicles in glioblastoma patients.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34888
Abstract: BACKGROUND Extracellular vesicles (EVs) play a critical role in intercellular communication under physiological and pathological conditions, including cancer. EVs cargo reflects their cell of origin, suggesting their utility as biomarkers. EVs are detected in several… read more here.
Keywords: salivary small; extracellular vesicles; saliva samples; evs ... See more keywords
A comprehensive prognostic signature for glioblastoma patients based on transcriptomics and single cell sequencing.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular oncology"
DOI: 10.1007/s13402-021-00612-1
Abstract: PURPOSE Glioblastoma (GBM) is the most common and deadly brain tumor. We aimed to reveal potential prognostic GBM marker genes, elaborate their functions, and build an effective a prognostic model for GBM patients. METHODS Through… read more here.
Keywords: single cell; gbm; gbm patients; comprehensive prognostic ... See more keywords
No prognostic differences between GBM-patients presenting with postoperative SMA-syndrome and GBM-patients involving cortico-spinal tract and primary motor cortex
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2020.117188
Abstract: BACKGROUND The supplementary motor area (SMA) is involved in several aspects of motor control and its can be associated to a contralateral motor deficit and speech disorders. After the resection of low-grade gliomas, this syndrome… read more here.
Keywords: tract; gbm patients; sma; motor ... See more keywords
Socioeconomic factors affecting survivorship of glioblastoma patients in the Philippines
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2022.02.007
Abstract: Glioblastoma (GBM) is the most common malignant primary brain tumor in adults worldwide. However, data on the survivorship of GBM patients in low- and middle-income countries is sparse. We determined whether socioeconomic factors such as… read more here.
Keywords: time; resection; glioblastoma; income ... See more keywords
The SHORT score for preoperative assessment of the risk for short-term survival in glioblastoma.
Sign Up to like & getrecommendations! Published in 2020 at "World neurosurgery"
DOI: 10.1016/j.wneu.2020.02.131
Abstract: BACKGROUND Despite recent improvements in treatment of glioblastoma (GBM), some patients still show a short survival. OBJECTIVE In this study, we sought to develop a new risk score for preoperative assessment of short-term survival (STS,… read more here.
Keywords: risk; score preoperative; short term; gbm patients ... See more keywords
PATH-24. DETECTION OF POINT MUTATIONS AND GENE FUSIONS FROM CIRCULATING CELL-FREE DNA (CFDNA) OF GLIOBLASTOMA (GBM) PATIENTS
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.705
Abstract: GBM is characterized by intratumoral heterogeneity. Tumor heterogeneity, clonal diversity and mutation acquisition hamper the ability to tailor personalized therapy for GBM. Tumor sampling has limited ability to accurately capture the molecular landscape of the… read more here.
Keywords: dna; gbm patients; cfdna; gene ... See more keywords
CSIG-24. miR-575 IS ASSOCIATED WITH WORSE SURVIVAL OF GBM PATIENTS AND ACTS AS A NOVEL ONCOGENE THROUGH TARGETING p27/CDKN1B AND BLID/BRCC2
Sign Up to like & getrecommendations! Published in 2018 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noy148.190
Abstract: Glioblastoma (GBM) patients currently face poor survival outcomes with an average survival period of less than 15 months, while only 3–5% of patients survive longer than 36 months. Although the mechanisms of tumorigenesis are still… read more here.
Keywords: mir 575; gbm; gbm patients; expression ... See more keywords
OS1.4 Liquid biopsy of the CSF in a series of GBM patients: preliminary results
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz126.017
Abstract: Liquid biopsy (LB) by cerebrospinal fluid (CSF) can be useful to identify circulating tumour DNA (ctDNA), thus offering information about the heterogeneity of the neoplastic genome. The aim of our study is to assess the… read more here.
Keywords: dna; gbm patients; tissue; liquid biopsy ... See more keywords
P14.68 Life expectancy in biopsied GBM patients: a single-centre experience
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz126.303
Abstract: The prognosis for patients with GBM remains dismal. The most aggressive multimodal therapy (maximally radical and safe tumour resection, followed by the Stupp protocol oncotherapy) has yielded the best treatment outcomes. Only a small proportion… read more here.
Keywords: biopsy; biopsied gbm; gbm patients; tumour ... See more keywords