Scutellarin Attenuates Lipopolysaccharide‐Induced Acute Lung Injury in Mice by Inhibiting M1 Macrophage Polarization via the GBP2/JAK2/STAT3 Signaling Pathway
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DOI: 10.1002/ptr.70099
Abstract: Uncontrolled inflammation and excessive M1 macrophage polarization are key drivers of acute lung injury (ALI). Scutellarin (SCU), a natural flavonoid compound, possesses anti‐inflammatory activity, but its precise mechanism remains unclear. This study aimed to investigate… read more here.
Keywords: jak2 stat3; macrophage polarization; lung injury; gbp2 ... See more keywords
G-strand binding protein 2 is involved in asexual and sexual development of Plasmodium berghei.
Sign Up to like & getrecommendations! Published in 2020 at "Parasitology international"
DOI: 10.1016/j.parint.2020.102059
Abstract: G-strand binding protein 2 (GBP2) is a Ser/Arg-rich (SR) protein involved in mRNA surveillance and nuclear mRNA quality control in yeast. However, the roles of GBP2 in virulence and sexual development in Plasmodium parasites are… read more here.
Keywords: gbp2; sexual development; berghei; development ... See more keywords
GBP2 enhances glioblastoma invasion through Stat3/fibronectin pathway
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DOI: 10.1038/s41388-020-1348-7
Abstract: Guanylate-binding protein 2 (GBP2) is an interferon-inducible large GTPase which is crucial to the protective immunity against microorganisms. However, its biological function in cancer remains largely unknown. Glioblastoma multiforme (GBM) is the most common and… read more here.
Keywords: gbp2; gbp2 expression; invasion; stat3 ... See more keywords
Subtyping of microsatellite stability colorectal cancer reveals guanylate binding protein 2 (GBP2) as a potential immunotherapeutic target
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004302
Abstract: Backgrounds Proficient-mismatch-repair or microsatellite stability (pMMR/MSS) colorectal cancer (CRC) has limited efficacy for immune checkpoint blockade (ICB) therapy and its underlying mechanism remains unclear. Guanylate binding protein 2 (GBP2) is a member of the GTPase… read more here.
Keywords: gbp2; mss crc; cancer; crc ... See more keywords
Plasma GBP2 promoter methylation is associated with advanced stages in breast cancer
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DOI: 10.1590/1678-4685-gmb-2019-0230
Abstract: Abstract Blood methylated cell-free DNA (cfDNA) as a minimally invasive cancer biomarker has great importance in cancer management. Guanylate binding protein 2 (GBP2) has been considered as a possible controlling factor in tumor development. GBP2… read more here.
Keywords: breast cancer; gbp2; promoter methylation; cancer ... See more keywords
6-Gingerol attenuates subarachnoid hemorrhage-induced early brain injury via GBP2/PI3K/AKT pathway in the rat model
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.882121
Abstract: Numerous studies have elucidated the neuroprotective effect of 6-gingerol in central nervous system diseases. However, the potential role and mechanism of 6-gingerol on early brain injury (EBI) after subarachnoid hemorrhage (SAH) remains poorly understood. Here,… read more here.
Keywords: pi3k akt; sah rats; akt pathway; gbp2 ... See more keywords
The Furin Protease Dependence and Antiviral GBP2 Sensitivity of Murine Leukemia Virus Infection Are Determined by the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site
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DOI: 10.3390/ijms25189987
Abstract: Host restriction factor GBP2 suppresses the replication of the ecotropic Moloney murine leukemia virus (E-MLV) by inhibiting furin protease, which cleaves the viral envelope glycoprotein (Env) into surface (SU) and transmembrane (TM) subunits. We analyzed… read more here.
Keywords: sequence; cleavage site; gbp2; amino acid ... See more keywords