Inducible GBP5 Mediates the Antiviral Response via Interferon-Related Pathways during Influenza A Virus Infection
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Innate Immunity"
DOI: 10.1159/000460294
Abstract: Guanylate binding protein (GBP) 5 belongs to the GBP family, which is involved in important cellular processes, including signal transduction, translation, vesicle trafficking, and exocytosis. Structurally, GBPs display a high degree of homology and share… read more here.
Keywords: inducible gbp5; response; mediates antiviral; gbp5 ... See more keywords
Critical role of guanylate binding protein 5 in tumor immune microenvironment and predictive value of immunotherapy response
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.984615
Abstract: Background: The guanylate-binding proteins (GBPs) are the latest potential targets of immunotherapy. However, the role of GBP5 in pan-cancer, including colorectal cancer (CRC), remains unclear. This study aims to explore the effect of GBP5 on… read more here.
Keywords: gbp5; response; guanylate binding; tumor ... See more keywords
The Proinflammatory Role of Guanylate-Binding Protein 5 in Inflammatory Bowel Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.926915
Abstract: NLRP3 inflammasome is implicated in the pathogenesis of inflammatory bowel diseases (IBD). Since guanylate-binding protein 5 (GBP5) induces the NLRP3 inflammasome activity, we aim to investigate the potential role of GBP5 in IBD pathogenesis. The… read more here.
Keywords: role; inflammatory bowel; expression; bowel diseases ... See more keywords
GBP5 Repression Suppresses the Metastatic Potential and PD-L1 Expression in Triple-Negative Breast Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9040371
Abstract: Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype because of its high metastatic potential. Immune evasion due to aberrant expression of programmed cell death ligand 1 (PD-L1) has also been reported recently… read more here.
Keywords: expression; tnbc; gbp5; breast cancer ... See more keywords