Clinical Characteristics and Exploratory Genomic Analyses of Germline BRCA1 or BRCA2 Mutations in Breast Cancer
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DOI: 10.1158/1541-7786.mcr-19-1108
Abstract: gBRCA1/2 mutations increase the incidence of breast cancer by interrupting the homologous recombination repair (HRR) pathway. Although gBRCA1 and gBRCA2 breast cancer have similar clinical profiles, different molecular characteristics have been observed. In this study,… read more here.
Keywords: gbrca2; cancer; breast cancer; gbrca1 ... See more keywords
Prevalence of Pathogenic Germline BRCA1/2 Variants and Their Association with Clinical Characteristics in Patients with Epithelial Ovarian Cancer in a Rural Area of Japan
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DOI: 10.3390/genes13061085
Abstract: The prevalence of germline BRCA1 or BRCA2 pathogenic variants (gBRCA1/2-PV) in patients with primary epithelial ovarian cancer (OC) in a rural area of Japan and their association with clinical characteristics, including treatment response and survival… read more here.
Keywords: germline brca1; area; ovarian cancer; clinical characteristics ... See more keywords