Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18233-x
Abstract: COVID-19 was declared a pandemic on March 11 by WHO, due to its great threat to global public health. The coronavirus main protease (Mpro, also called 3CLpro) is essential for processing and maturation of the… read more here.
Keywords: inhibit sars; efficaciously inhibit; main protease; gc376 ... See more keywords
Adaptive Mutation in the Main Protease Cleavage Site of Feline Coronavirus Renders the Virus More Resistant to Main Protease Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00907-22
Abstract: CoVs cause serious human infections, and antiviral drugs are currently approved to treat these infections. The development of protease-targeting therapeutics for CoV infection is hindered by resistance mutations. ABSTRACT The rapid global emergence of severe… read more here.
Keywords: protease; gc376; main protease; resistance ... See more keywords