GCB-type is a favorable prognostic factor in primary CNS diffuse large B-cell lymphomas
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2020.11.031
Abstract: Primary CNS lymphomas (PCNSLs) are aggressive diffuse large B-cell lymphomas (DLBCLs) limited to the CNS that generally have a poor prognosis. Classification of DLBCL into germinal center B-cell (GCB) and activated B-cell (non-GCB) subtypes has… read more here.
Keywords: gcb; non gcb; cns; gcb type ... See more keywords
Superior survival in diffuse large B cell lymphoma of the bone with immune rich tumor microenvironment
Sign Up to like & getrecommendations! Published in 2025 at "Blood Cancer Journal"
DOI: 10.1038/s41408-025-01291-z
Abstract: With tumor genomic and gene-expression profiling (GEP), this study investigated the immune-molecular signatures of a unique cohort of diffuse large B-cell lymphoma of the bone (bone-DLBCL), including primary bone (PB-DLBCL, n = 52) and polyostotic-DLBCL (n = 20), in… read more here.
Keywords: dlbcl; nodal dlbcl; immune rich; gcb ... See more keywords
Twenty‐five years of GCB: Putting the biology into global change
Sign Up to like & getrecommendations! Published in 2020 at "Global Change Biology"
DOI: 10.1111/gcb.14921
Abstract: The study and impact of global change has undergone dramatic transformations over the last 25 years. Global change in the early 1990s was viewed predominantly as the domain of the physical and chemical sciences, with… read more here.
Keywords: journal; global change; research; gcb ... See more keywords
Prediction and Characterization of Diffuse Large B-Cell Lymphoma (DLBCL) Cell of Origin (COO) Subtypes Using Genomic Features from Targeted Next-Generation Sequencing
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-116677
Abstract: Introduction: DLBCL has two COO subtypes: Activated B Cell (ABC) and Germinal Center B cell (GCB). Patients with the ABC subtype have a poor prognosis compared to those with GCB, and COO can be predictive… read more here.
Keywords: gcb; medicine; consultancy honoraria; coo ... See more keywords
Real-World Outcomes of Frontline Polatuzumab and Impact of Frailty in Older Adults with Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-202741
Abstract: Introduction The FDA approval of polatuzumab with rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-RCHP) in 2023 has enriched the treatment landscape for newly diagnosed diffuse large B-cell lymphoma (DLBCL). In the phase III POLARIX trial, patients… read more here.
Keywords: dlbcl; newly diagnosed; real world; pts yrs ... See more keywords
Genomic and immune determinants of response to CD3 x CD20 bispecific antibodies in aggressive B-cell lymphoma
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-3542
Abstract: CD3 x CD20 bispecific antibodies (BsAb)have been approved for use in relapsed/refractory (R/R) diffuse large B-cell lymphomas (DLBCLs) based on its deep and durable response and manageable toxicity profiles. While emerging data suggest that tumor… read more here.
Keywords: gcb hot; cd3 cd20; response; cell ... See more keywords
A super-SILAC based proteomics analysis of diffuse large B-cell lymphoma-NOS patient samples to identify new proteins that discriminate GCB and non-GCB lymphomas
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0223260
Abstract: Diffuse large B-cell lymphoma—not otherwise specified (DLBCL-NOS) is a large and heterogeneous subgroup of non-Hodgkin lymphoma. DLBCL can be subdivided into germinal centre B-cell like (GCB) and activated B-cell like (ABC or non-GCB) using a… read more here.
Keywords: gcb; lymphoma; non gcb; gcb dlbcl ... See more keywords
Clinicopathological features of primary central nervous system diffuse large B cell lymphoma: Experience from a Tertiary Center in North India
Sign Up to like & getrecommendations! Published in 2020 at "Surgical Neurology International"
DOI: 10.25259/sni_314_2020
Abstract: Background: Primary central nervous system-diffuse large B-cell lymphoma (PCNS-DLBCL) is a rare extra-nodal Non-Hodgkin lymphoma. There is relative paucity of literature on PCNSL from Indian subcontinent. We aimed to analyze the clinicopathological features of PCNSL… read more here.
Keywords: gcb; central nervous; lymphoma; center ... See more keywords
Towards genomic-based prognostication and precision therapy for diffuse large B-cell lymphoma
Sign Up to like & getrecommendations! Published in 2020 at "Haematologica"
DOI: 10.3324/haematol.2020.255448
Abstract: large B-cell lymphoma (DLBCL) is complicated by its great clinical and molecular heterogeneity. Twenty years ago, two distinct cell-of-origin (COO) subtypes were identified based on distinct gene expression profiles that reflect different stages of B-cell… read more here.
Keywords: gcb; dlbcl; dlbcl patients; bcl2 ... See more keywords
Universal Method of Compatibility Assessment for Novel Ablation Technologies With Different 3D Navigation Systems
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.917218
Abstract: Background New technologies for ablation procedures are often produced by different companies with no cross-compatibility out of the box. This is not a negligible clinical problem since those separately developed devices are often used together.… read more here.
Keywords: setup; eam; rhythmia; gcb ... See more keywords