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   Articles with "gcgr" as a keyword



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GLP-2 receptor signaling controls circulating bile acid levels but not glucose homeostasis in Gcgr−/− mice and is dispensable for the metabolic benefits ensuing after vertical sleeve gastrectomy

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recommendations! Published in 2018 at "Molecular Metabolism"

DOI: 10.1016/j.molmet.2018.06.006

Abstract: Objective Therapeutic interventions that improve glucose homeostasis such as attenuation of glucagon receptor (Gcgr) signaling and bariatric surgery share common metabolic features conserved in mice and humans. These include increased circulating levels of bile acids… read more here.

Keywords: glucose homeostasis; gcgr mice; gcgr; glp ... See more keywords

Negative allosteric modulation of the glucagon receptor by RAMP2

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recommendations! Published in 2022 at "Cell"

DOI: 10.1101/2022.08.30.505955

Abstract: Receptor activity-modifying proteins (RAMPs) modulate the activity of many Family B heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs). The glucagon receptor (GCGR), a Family B GPCR responsible for maintenance of proper blood sugar levels,… read more here.

Keywords: gcgr; ramp2; receptor; negative allosteric ... See more keywords
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RAMP2 Influences Glucagon Receptor Pharmacology via Trafficking and Signaling

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recommendations! Published in 2017 at "Endocrinology"

DOI: 10.1210/en.2016-1755

Abstract: Endogenous satiety hormones provide an attractive target for obesity drugs. Glucagon causes weight loss by reducing food intake and increasing energy expenditure. To further understand the cellular mechanisms by which glucagon and related ligands activate… read more here.

Keywords: gcgr; microscopy; ramp2; glucagon receptor ... See more keywords
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Hepatic TORC2 Signaling Facilitates Acute Glucagon-Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice.

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recommendations! Published in 2022 at "Diabetes"

DOI: 10.2337/db21-1018

Abstract: Long term glucagon receptor (GCGR) agonism is associated with hyperglycemia and glucose intolerance, while acute GCGR agonism enhances whole-body insulin sensitivity and hepatic AKTSer473 phosphorylation. These divergent effects establish a critical gap in knowledge surrounding… read more here.

Keywords: rictor; gcgr; mice; receptor ... See more keywords

Conformation Transition of Intracellular Part of Glucagon Receptor in Complex With Agonist Glucagon by Conventional and Accelerated Molecular Dynamics Simulations

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recommendations! Published in 2019 at "Frontiers in Chemistry"

DOI: 10.3389/fchem.2019.00851

Abstract: The inactive conformations of glucagon receptor (GCGR) are widely reported by crystal structures that support the precision structure for drug discovery of type 2 diabetes. The previous study shows that the intracellular part is open… read more here.

Keywords: glu gcgr; glucagon; gcgr; intracellular part ... See more keywords