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   Articles with "gck" as a keyword



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Glucokinase mutations in pediatric patients with impaired fasting glucose

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recommendations! Published in 2017 at "Acta Diabetologica"

DOI: 10.1007/s00592-017-1021-y

Abstract: AbstractAimsOur aim was to detect the frequency of glucokinase (GCK) gene mutations in a cohort of patients with impaired fasting glucose and to describe the clinical manifestations of identified variants. We also aimed at predicting… read more here.

Keywords: patients impaired; glucokinase; impaired fasting; fasting glucose ... See more keywords
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Nanosecond-Timescale Dynamics and Conformational Heterogeneity in Human GCK Regulation and Disease.

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recommendations! Published in 2020 at "Biophysical journal"

DOI: 10.1016/j.bpj.2019.12.036

Abstract: Human glucokinase (GCK) is the prototypic example of an emerging class of proteins with allosteric-like behavior that originates from intrinsic polypeptide dynamics. High-resolution NMR investigations of GCK have elucidated millisecond-timescale dynamics underlying allostery. In contrast,… read more here.

Keywords: heterogeneity; timescale dynamics; nanosecond timescale; cooperativity ... See more keywords
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Cilium Length and Intraflagellar Transport Regulation by Kinases PKG-1 and GCK-2 in Caenorhabditis elegans Sensory Neurons

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recommendations! Published in 2018 at "Molecular and Cellular Biology"

DOI: 10.1128/mcb.00612-17

Abstract: ABSTRACT To understand how ciliopathies such as polycystic kidney disease or Bardet-Biedl syndrome develop, we need to understand the basic molecular mechanisms underlying cilium development. Cilium growth depends on the presence of functional intraflagellar transport… read more here.

Keywords: pkg gck; kinases pkg; kinase; intraflagellar transport ... See more keywords
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The Inhibition of Gck Affect MAPK Cascade in Multiple Myeloma

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recommendations! Published in 2018 at "Blood"

DOI: 10.1182/blood-2018-99-117557

Abstract: Introduction: Germinal Center Kinase (GCK) is an essential regulator of stress-activated MAPK core signaling pathways. Recent studies revealing the role of GCK in tumorigenesis and cancer progression have generated increasing interest in validating GCK as… read more here.

Keywords: inhibition; mapk cascade; cell; myc ... See more keywords
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Sequence and expression analysis of glucokinase mRNA from herbivorous Giant gourami (Osphronemus goramy)

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recommendations! Published in 2021 at "Biodiversitas"

DOI: 10.13057/biodiv/d220227

Abstract: Abstract. Sari DN, Nasrullah H, Ekasari J, Suprayudi MA, Alimuddin A. 2021. Sequence and expression analysis of glucokinase mRNA from herbivorous Giant gourami (Osphronemus goramy). Biodiversitas 22: 741-750. Glucokinase (GCK) is one of the enzymes… read more here.

Keywords: sequence expression; giant gourami; gck; gourami ... See more keywords
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Functional Inactivation of Drosophila GCK Orthologs Causes Genomic Instability and Oxidative Stress in a Fly Model of MODY-2

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recommendations! Published in 2021 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms22020918

Abstract: Maturity-onset diabetes of the young (MODY) type 2 is caused by heterozygous inactivating mutations in the gene encoding glucokinase (GCK), a pivotal enzyme for glucose homeostasis. In the pancreas GCK regulates insulin secretion, while in… read more here.

Keywords: drosophila gck; genomic instability; mody; gck ... See more keywords