The association between genetic polymorphisms in GCKR and gout: A systematic review and meta-analysis
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DOI: 10.1097/md.0000000000042447
Abstract: Background: As far as we know, there are no studies summarizing single nucleotide polymorphism (SNP) in the GCKR gene associated with gout, and the association of SNP in the GCKR gene with gout is controversial.… read more here.
Keywords: associated gout; gout; gckr gene; gckr ... See more keywords
Additive genetic effect of GCKR, G6PC2, and SLC30A8 variants on fasting glucose levels and risk of type 2 diabetes
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DOI: 10.1371/journal.pone.0269378
Abstract: Impaired glucose tolerance is a major risk factor for type 2 diabetes (T2D) and several cardiometabolic disorders. To identify genetic loci underlying fasting glucose levels, we conducted an analysis of 9,232 individuals of European ancestry… read more here.
Keywords: fasting glucose; gckr; glucose levels; g6pc2 ... See more keywords
Pleiotropic Effects of Common and Rare GCKR Exonic Mutations on Cardiometabolic Traits
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DOI: 10.3390/genes13030491
Abstract: Background: The common non-synonymous mutation of the glucokinase regulator (GCKR) gene, namely rs1260326, is widely reported to have pleiotropic effects on cardio-metabolic traits and hematological parameters. Objective: This study aimed to identify whether other GCKR… read more here.
Keywords: gckr exonic; gckr; rare gckr; exonic mutations ... See more keywords