Genetic variation at the catalytic subunit of glutamate cysteine ligase contributes to the susceptibility to sporadic colorectal cancer: a pilot study.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology reports"
DOI: 10.1007/s11033-022-07406-0
Abstract: BACKGROUND Glutathione is a tripeptide detoxifying a variety of exogenous and endogenous free radicals and carcinogens, and a deficiency of glutathione is associated with an increased host susceptibility to oxidative stress, a pathological condition implicated… read more here.
Keywords: glutamate cysteine; gclc; cancer; catalytic subunit ... See more keywords
The Thioredoxin Reductase-1 Inhibitor Aurothioglucose Enhances Glutathione-dependent Antioxidant Responses in a Murine Model of Bronchopulmonary Dysplasia
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.048
Abstract: Introduction Therapeutic oxygen contributes to the development of bronchopulmonary dysplasia (BPD). The thioredoxin reductase-1 (TrxR1) inhibitor aurothioglucose (ATG) is protective in our murine BPD model. Improved lung structure in ATG-treated newborn mice was associated with… read more here.
Keywords: bronchopulmonary dysplasia; antioxidant responses; atg; gsh ... See more keywords
Genetic susceptibility analysis of GCLC rs17883901 polymorphism to preeclampsia in Chinese Han women
Sign Up to like & getrecommendations! Published in 2020 at "Gynecological Endocrinology"
DOI: 10.1080/09513590.2020.1725970
Abstract: Abstract Preeclampsia (PE) is a specific obstetric disorder that may result in maternal and neonatal morbidity and mortality. Increasing evidence has been indicated that some candidate genes related to oxidative stress, such as glutamate-cysteine ligase,… read more here.
Keywords: rs17883901 polymorphism; late onset; gclc; gclc rs17883901 ... See more keywords
Association of GCLM -588C/T and GCLC -129T/C Promoter Polymorphisms of Genes Coding the Subunits of Glutamate Cysteine Ligase with Ischemic Heart Disease Development in Kazakhstan Population
Sign Up to like & getrecommendations! Published in 2017 at "Disease Markers"
DOI: 10.1155/2017/4209257
Abstract: Background Glutamate cysteine ligase (GCL) is a rate-limiting enzyme in synthesis of glutathione. Evidence suggests that genetic variations in the promoter region of genes coding a catalytic subunit (GCLC -129T/C) and a modifier subunit (GCLM… read more here.
Keywords: risk; gclm 588c; disease; gclc ... See more keywords