Recognition of a structural domain (RWDBD) in Gcn1 proteins that interacts with the RWD domain containing proteins
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DOI: 10.1186/s13062-017-0184-3
Abstract: The protein Gcn1 (General control non-derepressible 1) is found in virtually all eukaryotes, and is a key component of the general amino acid control signal transduction pathway. This pathway is best known for its importance… read more here.
Keywords: containing proteins; gcn2; structural domain; gcn1 ... See more keywords
A genetic approach to identify amino acids in Gcn1 required for Gcn2 activation
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DOI: 10.1371/journal.pone.0277648
Abstract: The protein kinase Gcn2 is present in virtually all eukaryotic cells. It is best known for its role in helping cells cope with amino acid starvation. Under starvation, Gcn2 phosphorylates the α subunit of the… read more here.
Keywords: amino acids; gcn2; gcn1; gcn1 gcn2 ... See more keywords
Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage
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DOI: 10.3390/ijms23063201
Abstract: GCN1 is an evolutionarily-conserved ribosome-binding protein that mediates the amino acid starvation response as well as the ribotoxic stress response. We previously demonstrated that Gcn1 mutant mice lacking the GCN2-binding domain suffer from growth retardation… read more here.
Keywords: tamoxifen treatment; mice; weight loss; gcn1 ... See more keywords