GCN2 is essential for CD8+ T cell survival and function in murine models of malignant glioma
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-019-02441-6
Abstract: Amino acid deprivation is a strategy that malignancies utilize to blunt anti-tumor T-cell immune responses. It has been proposed that amino acid insufficiency in T-cells is detected by GCN2 kinase, which through phosphorylation of EIF2α,… read more here.
Keywords: cd8 cell; cd8; gcn2; cd8 cells ... See more keywords
GCN2 phosphorylates HIV-1 integrase and decreases HIV-1 replication by limiting viral integration
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02276-0
Abstract: GCN2 is a serine/threonine kinase involved in cellular stress response related to amino acid starvation. Previously, we showed that GCN2 interacts with HIV-1 integrase and is activated during HIV-1 infection. Herein, we identified HIV-1 integrase… read more here.
Keywords: integrase; integration; gcn2; gcn2 phosphorylates ... See more keywords
Towards a model of GCN2 activation
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Society Transactions"
DOI: 10.1042/bst20190331
Abstract: Cells must be able to sense and adapt to their surroundings to thrive in a dynamic environment. Key to adapting to a low nutrient environment is the Integrated Stress Response (ISR), a short-lived pathway that… read more here.
Keywords: towards model; activation; gcn2 activation; gcn2 ... See more keywords
GCN2: roles in tumour development and progression
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20211252
Abstract: GCN2 (general control nonderepessible 2) is an eIF2α kinase responsible for entirely rewiring the metabolism of cells when they are put under amino acid starvation stress. Recently, there has been renewed interest in GCN2 as… read more here.
Keywords: gcn2; development; roles tumour; gcn2 roles ... See more keywords
Activation of GCN2 by the ribosomal P-stalk
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1813352116
Abstract: Significance General control nonderepressible 2 (GCN2) phosphorylates eIF2α, regulating translation in response to nutritional stress. Here, we show that although tRNA stimulates purified, recombinant human GCN2 in vitro, mammalian ribosomes are even more potent GCN2… read more here.
Keywords: ribosomal stalk; gcn2; gcn2 activation; stalk ... See more keywords
The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2121251119
Abstract: Significance In this study, we define a regulatory pathway controlling tissue-resident macrophages during stress through the translational control of a subset of messenger RNAs (mRNAs) and transcriptional reprogramming. Our data reveal that the GCN2-eIF2α pathway… read more here.
Keywords: clearance; gcn2; red blood; liver macrophages ... See more keywords
Differential requirements for P stalk components in activating yeast protein kinase Gcn2 by stalled ribosomes during stress.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2300521120
Abstract: The General Amino Acid Control is a conserved response to amino acid starvation involving activation of protein kinase Gcn2, which phosphorylates eukaryotic initiation factor 2 (eIF2α) with attendant inhibition of global protein synthesis and increased… read more here.
Keywords: gcn2; protein kinase; requirements stalk; kinase gcn2 ... See more keywords
Autophagy contributes to sulfonylurea herbicide tolerance via GCN2-independent regulation of amino acid homeostasis
Sign Up to like & getrecommendations! Published in 2018 at "Autophagy"
DOI: 10.1080/15548627.2017.1407888
Abstract: ABSTRACT Sulfonylurea (SU) herbicides inhibit branched-chain amino acid (BCAA) biosynthesis by targeting acetolactate synthase. Plants have evolved target-site resistance and metabolic tolerance to SU herbicides; the GCN2 (general control non-repressible 2) pathway is also involved… read more here.
Keywords: amino acid; tolerance; gcn2; autophagy ... See more keywords
Multi-omics reveals a relationship between endometrial amino acid metabolism and autophagy in women with recurrent miscarriage
Sign Up to like & getrecommendations! Published in 2021 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioab101
Abstract: Abstract Deterioration of the endometrial environment is an essential cause of recurrent miscarriage (RM). However, current studies in terms of endometrial amino acid metabolic characterization and autophagy are still inadequate. We tried to (1) identify… read more here.
Keywords: amino; amino acid; acid metabolism; gcn2 ... See more keywords
Ethylene modulates translation dynamics in Arabidopsis under submergence via GCN2 and EIN2
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm7863
Abstract: General translational repression is a key process that reduces energy consumption under hypoxia. Here, we show that plant stress-activated general control nonderepressible 2 (GCN2) was activated to regulate the reduction in polysome loading during submergence… read more here.
Keywords: gcn2; modulates translation; translation dynamics; ethylene modulates ... See more keywords
The integrated stress response contributes to tRNA synthetase–associated peripheral neuropathy
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.abb3414
Abstract: Description Defeating peripheral neuropathy The mechanisms underlying peripheral neuropathies are not well understood. Spaulding et al. studied mouse models of the inherited Charcot-Marie-Tooth (CMT) disease, which is caused by mutations in transfer RNA (tRNA) synthetases.… read more here.
Keywords: response; gcn2; peripheral neuropathy; integrated stress ... See more keywords