Towards a model of GCN2 activation
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Society Transactions"
DOI: 10.1042/bst20190331
Abstract: Cells must be able to sense and adapt to their surroundings to thrive in a dynamic environment. Key to adapting to a low nutrient environment is the Integrated Stress Response (ISR), a short-lived pathway that… read more here.
Keywords: towards model; activation; gcn2 activation; gcn2 ... See more keywords
Activation of GCN2 by the ribosomal P-stalk
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1813352116
Abstract: Significance General control nonderepressible 2 (GCN2) phosphorylates eIF2α, regulating translation in response to nutritional stress. Here, we show that although tRNA stimulates purified, recombinant human GCN2 in vitro, mammalian ribosomes are even more potent GCN2… read more here.
Keywords: ribosomal stalk; gcn2; gcn2 activation; stalk ... See more keywords
A genetic approach to identify amino acids in Gcn1 required for Gcn2 activation
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0277648
Abstract: The protein kinase Gcn2 is present in virtually all eukaryotic cells. It is best known for its role in helping cells cope with amino acid starvation. Under starvation, Gcn2 phosphorylates the α subunit of the… read more here.
Keywords: amino acids; gcn2; gcn1; gcn1 gcn2 ... See more keywords