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   Articles with "gcn2 activation" as a keyword



Towards a model of GCN2 activation

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recommendations! Published in 2019 at "Biochemical Society Transactions"

DOI: 10.1042/bst20190331

Abstract: Cells must be able to sense and adapt to their surroundings to thrive in a dynamic environment. Key to adapting to a low nutrient environment is the Integrated Stress Response (ISR), a short-lived pathway that… read more here.

Keywords: towards model; activation; gcn2 activation; gcn2 ... See more keywords

Activation of GCN2 by the ribosomal P-stalk

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recommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.1813352116

Abstract: Significance General control nonderepressible 2 (GCN2) phosphorylates eIF2α, regulating translation in response to nutritional stress. Here, we show that although tRNA stimulates purified, recombinant human GCN2 in vitro, mammalian ribosomes are even more potent GCN2… read more here.

Keywords: ribosomal stalk; gcn2; gcn2 activation; stalk ... See more keywords

GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling.

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recommendations! Published in 2025 at "Science"

DOI: 10.1126/science.ads8728

Abstract: During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stresses. GCN2 activation has been linked… read more here.

Keywords: activation; couples gcn2; amino acid; gcn1 couples ... See more keywords

A genetic approach to identify amino acids in Gcn1 required for Gcn2 activation

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recommendations! Published in 2022 at "PLOS ONE"

DOI: 10.1371/journal.pone.0277648

Abstract: The protein kinase Gcn2 is present in virtually all eukaryotic cells. It is best known for its role in helping cells cope with amino acid starvation. Under starvation, Gcn2 phosphorylates the α subunit of the… read more here.

Keywords: amino acids; gcn2; gcn1; gcn1 gcn2 ... See more keywords