Prolyl-tRNA synthetase inhibition promotes cell death in SK-MEL-2 cells through GCN2-ATF4 pathway activation.
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DOI: 10.1016/j.bbrc.2017.01.045
Abstract: Protein translation is highly activated in cancer tissues through oncogenic mutations and amplifications, and this can support survival and aberrant proliferation. Therefore, blocking translation could be a promising way to block cancer progression. The process… read more here.
Keywords: death; prolyl trna; gcn2 atf4; atf4 pathway ... See more keywords