GCN2 suppression attenuates cerebral ischemia in mice by reducing apoptosis and endoplasmic reticulum (ER) stress through the blockage of FoxO3a-regulated ROS production.
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DOI: 10.1016/j.bbrc.2019.05.181
Abstract: Ischemic stroke is one of the leading causes of morbidity and mortality among human worldwide. Unfortunately, cerebral I/R still lacks effective therapeutic targets and strategies. In the study, we found that general control nonderepressible 2… read more here.
Keywords: suppression; gcn2 suppression; ros production; stress ... See more keywords