Phosphorylation of histone H4 at serine 1 is associated with GCN5 and mediates autophagy in osteosarcoma bone cell lines.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cellular physiology"
DOI: 10.1002/jcp.29434
Abstract: Histone modification is critical for the process of autophagy in osteosarcoma. Whether phosphorylated histone H4 (H4) mediates autophagy remains to be seen. Here, we aimed to investigate the effects of general control nonderepressible 5 (GCN5)-evoked… read more here.
Keywords: gcn5; autophagy osteosarcoma; histone; phosphorylation ... See more keywords
The Lysine Acetyltransferase GCN5 Is Required for iNKT Cell Development through EGR2 Acetylation.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.06.065
Abstract: The development of CD1d-restricted invariant natural killer T (iNKT) cells, a population that is critical for both innate and adaptive immunity, is regulated by multiple transcription factors, but the molecular mechanisms underlying how the transcriptional… read more here.
Keywords: gcn5; acetylation; cell development; inkt cell ... See more keywords
GCN5 Regulates FGF Signaling and Activates Selective MYC Target Genes during Early Embryoid Body Differentiation
Sign Up to like & getrecommendations! Published in 2018 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2017.11.009
Abstract: Summary Precise control of gene expression during development is orchestrated by transcription factors and co-regulators including chromatin modifiers. How particular chromatin-modifying enzymes affect specific developmental processes is not well defined. Here, we report that GCN5,… read more here.
Keywords: early embryoid; gcn5; fgf signaling; differentiation ... See more keywords
General Control Nonrepressed Protein 5 Modulates Odontogenic Differentiation Through NF-κB Pathway in Tumor Necrosis Factor-α-Mediated Impaired Human Dental Pulp Stem Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular reprogramming"
DOI: 10.1089/cell.2021.0113
Abstract: Dental pulp stem cells (DPSCs) from pulpitis patients showed defective osteogenic differentiation. However, as the most well-studied histone acetyltransferase, the impaired general control nonrepressed protein 5 (GCN5) plays essential roles in various developmental processes. The… read more here.
Keywords: dental pulp; dpscs; odontogenic differentiation; gcn5 ... See more keywords
GCN5 contributes to intracellular lipid accumulation in human primary cardiac stromal cells from patients affected by Arrhythmogenic cardiomyopathy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17396
Abstract: Arrhythmogenic cardiomyopathy (ACM) is a genetic disease associated with sudden cardiac death and cardiac fibro‐fatty replacement. Over the last years, several works have demonstrated that different epigenetic enzymes can affect not only gene expression changes… read more here.
Keywords: cardiac; arrhythmogenic cardiomyopathy; accumulation; lipid accumulation ... See more keywords
CBP and Gcn5 drive zygotic genome activation independently of their catalytic activity
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adf2687
Abstract: Zygotic genome activation (ZGA) is a crucial step of embryonic development. So far, little is known about the role of chromatin factors during this process. Here, we used an in vivo RNA interference reverse genetic… read more here.
Keywords: genome activation; gcn5; zygotic genome; zga ... See more keywords
Ada2 and Ada3 Regulate Hyphal Growth, Asexual Development, and Pathogenicity in Beauveria bassiana by Maintaining Gcn5 Acetyltransferase Activity
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00281-23
Abstract: The histone acetyltransferase Gcn5 ortholog contributes significantly to the growth and development of various fungi. In this study, we found that Ada2 and Ada3 have critical regulatory effects on Gcn5 enzyme activity and influence the… read more here.
Keywords: acetyltransferase; histone; growth; ada2 ada3 ... See more keywords
Abstract 4333: GCN5 positively correlates with c-MYC in non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs18-4333
Abstract: Lung cancer causes the highest mortality in cancer-related deaths. Definition of novel molecular targets is needed since these cancers often become resistant to existing therapies. Epigenetic modifications may provide such targets. Recent reports suggest that… read more here.
Keywords: lung; gcn5; lung cancer; cancer ... See more keywords
The effects of β-catenin on cardiomyogenesis via Islet-1 and MLIP ubiquitination
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Biology and Medicine"
DOI: 10.1177/15353702221119792
Abstract: Mesenchymal stem cells (MSCs) can treat myocardial injury–related diseases by differentiating into cardiomyocytes. Islet-1 plays an essential role in cardiac maturation. We have discovered that Islet-1 plays a crucial role in the histone acetylation regulation… read more here.
Keywords: expression; mlip; gcn5; mlip ubiquitination ... See more keywords
IFN-α confers epigenetic regulation of HBV cccDNA minichromosome by modulating GCN5-mediated succinylation of histone H3K79 to clear HBV cccDNA
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Epigenetics"
DOI: 10.1186/s13148-020-00928-z
Abstract: Background Hepatitis B virus covalently closed circular DNA (HBV cccDNA) is assembled by histones and non-histones into a chromatin-like cccDNA minichromosome in the nucleus. The cellular histone acetyltransferase GCN5, displaying succinyltransferase activity, is recruited onto… read more here.
Keywords: gcn5; cccdna; cccdna minichromosome; succinylation ... See more keywords
Differential Effects of Histone Acetyltransferase GCN5 or PCAF Knockdown on Urothelial Carcinoma Cells
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18071449
Abstract: Disturbances in histone acetyltransferases (HATs) are common in cancers. In urothelial carcinoma (UC), p300 and CBP are often mutated, whereas the GNAT family HATs GCN5 and PCAF (General Control Nonderepressible 5, p300/CBP-Associated Factor) are often… read more here.
Keywords: gcn5; pcaf knockdown; gcn5 pcaf; urothelial carcinoma ... See more keywords