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   Articles with "gcsf" as a keyword



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Bortezomib and cyclophosphamide based chemo-mobilization in multiple myeloma

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recommendations! Published in 2020 at "International Journal of Hematology"

DOI: 10.1007/s12185-020-02973-z

Abstract: Hematopoietic stem and progenitor cell (HSPC) mobilization regimens in multiple myeloma typically use filgrastim (GCSF) alone or combination of GCSF with plerixafor or high-dose cyclophosphamide. Murine model and human studies have shown HSPC mobilization potential… read more here.

Keywords: gcsf; multiple myeloma; bortezomib; mobilization ... See more keywords
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198P Complications associated with prolonged GCSF with dose-dense EC chemotherapy for early breast cancer patients

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recommendations! Published in 2021 at "Annals of Oncology"

DOI: 10.1016/j.annonc.2021.08.479

Abstract: Background: Primary granulocyte-colony stimulating factor (GSCF) prophylaxis with dose-dense chemotherapy for early stage breast cancer is routine practice to prevent febrile neutropenia (FN). Our current practice administers 7 days of GCSF, which reduces the FN… read more here.

Keywords: gcsf; dense; breast cancer; toxicity ... See more keywords

Impacts of a Zwitterionic Peptide on its Fusion Protein.

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recommendations! Published in 2022 at "Bioconjugate chemistry"

DOI: 10.1021/acs.bioconjchem.2c00176

Abstract: Therapeutic proteins frequently need to be modified with high-molecular-weight molecules to improve their pharmacokinetic properties. The genetic linkage of therapeutic proteins to a high-molecular-weight zwitterionic peptide, termed EKP, offers a promising approach. As with any… read more here.

Keywords: zwitterionic peptide; fusion protein; ekp gcsf; gcsf ... See more keywords
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Granulocyte colony-stimulating factor (GCSF) fused with Fc Domain produced from E. coli is less effective than Polyethylene Glycol-conjugated GCSF

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-06726-7

Abstract: Human granulocyte colony-stimulating factor (GCSF) is a well-known cytokine for neutropenia treatment. However, daily injections are required due to the short circulating half-life of the protein. To overcome this bottleneck, we fused GCSF with the… read more here.

Keywords: gcsf; peg gcsf; stimulating factor; factor gcsf ... See more keywords
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Synonymous codon changes at the 5′-end of the gene strongly impact the heterologous protein expression in Escherichia coli

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recommendations! Published in 2017 at "Applied Biochemistry and Microbiology"

DOI: 10.1134/s0003683817030024

Abstract: This study describes the impact of 5′-end codon modulation on the expression of a heterologous gene, human granulocyte colony stimulating factor (GCSF), in Escherichia coli. Fourteen different constructs (pGCSF-01 to pGCSF-14) carrying single or multiple… read more here.

Keywords: synonymous codon; gcsf; escherichia coli; expression ... See more keywords
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Filgrastim Administered after Early Assessment Bone Marrow Biopsy during 7+3 Induction Therapy for Acute Myeloid Leukemia Reduces Length of Hospital Stay

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recommendations! Published in 2019 at "Blood"

DOI: 10.1182/blood-2019-131293

Abstract: Background National guidelines for acute myeloid leukemia (AML) therapy do not routinely recommend granulocyte colony stimulating factors (GCSF) during intensive induction therapy. Randomized trials have showed GCSF administration immediately after induction chemotherapy does improve time… read more here.

Keywords: recovery; gcsf; time; d14bm ... See more keywords

Use of granulocyte colony stimulating factor (GCSF) in patients receiving highly myelosuppressive chemotherapy for breast cancer.

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recommendations! Published in 2017 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.2017.35.15_suppl.e21677

Abstract: e21677Background:We hypothesized that GCSF use may be suboptimal in the real world despite prior research that shows prophylaxis with GCSF can reduce neutropenic fevers and hospitalizations. Our aims were to characterize patterns of GCSF use… read more here.

Keywords: chemotherapy; gcsf; patients receiving; breast cancer ... See more keywords

In silico design of fusion toxin DT389GCSF and comparison of interaction it with GCSF receptor rather than DT486GCSF.

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recommendations! Published in 2018 at "Current computer-aided drug design"

DOI: 10.2174/1573409914666181012151242

Abstract: BACKGROUND The negative effect of chemotherapy and radiotherapy on normal tissues as well as the high expense and length of these treatments have recently attracted researchers to the new methods that specifically affect cancerous tissues… read more here.

Keywords: protein; gcsf; fusion toxin; fusion ... See more keywords