Bortezomib and cyclophosphamide based chemo-mobilization in multiple myeloma
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Hematology"
DOI: 10.1007/s12185-020-02973-z
Abstract: Hematopoietic stem and progenitor cell (HSPC) mobilization regimens in multiple myeloma typically use filgrastim (GCSF) alone or combination of GCSF with plerixafor or high-dose cyclophosphamide. Murine model and human studies have shown HSPC mobilization potential… read more here.
Keywords: gcsf; multiple myeloma; bortezomib; mobilization ... See more keywords
198P Complications associated with prolonged GCSF with dose-dense EC chemotherapy for early breast cancer patients
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Oncology"
DOI: 10.1016/j.annonc.2021.08.479
Abstract: Background: Primary granulocyte-colony stimulating factor (GSCF) prophylaxis with dose-dense chemotherapy for early stage breast cancer is routine practice to prevent febrile neutropenia (FN). Our current practice administers 7 days of GCSF, which reduces the FN… read more here.
Keywords: gcsf; dense; breast cancer; toxicity ... See more keywords
Impacts of a Zwitterionic Peptide on its Fusion Protein.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00176
Abstract: Therapeutic proteins frequently need to be modified with high-molecular-weight molecules to improve their pharmacokinetic properties. The genetic linkage of therapeutic proteins to a high-molecular-weight zwitterionic peptide, termed EKP, offers a promising approach. As with any… read more here.
Keywords: zwitterionic peptide; fusion protein; ekp gcsf; gcsf ... See more keywords
Granulocyte colony-stimulating factor (GCSF) fused with Fc Domain produced from E. coli is less effective than Polyethylene Glycol-conjugated GCSF
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06726-7
Abstract: Human granulocyte colony-stimulating factor (GCSF) is a well-known cytokine for neutropenia treatment. However, daily injections are required due to the short circulating half-life of the protein. To overcome this bottleneck, we fused GCSF with the… read more here.
Keywords: gcsf; peg gcsf; stimulating factor; factor gcsf ... See more keywords
Synonymous codon changes at the 5′-end of the gene strongly impact the heterologous protein expression in Escherichia coli
Sign Up to like & getrecommendations! Published in 2017 at "Applied Biochemistry and Microbiology"
DOI: 10.1134/s0003683817030024
Abstract: This study describes the impact of 5′-end codon modulation on the expression of a heterologous gene, human granulocyte colony stimulating factor (GCSF), in Escherichia coli. Fourteen different constructs (pGCSF-01 to pGCSF-14) carrying single or multiple… read more here.
Keywords: synonymous codon; gcsf; escherichia coli; expression ... See more keywords
Abstract P1-07-16: Real-World Duration of Sacituzumab Govitecan-hziy Treatment in Patients with Metastatic Triple-Negative Breast Cancer
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.sabcs24-p1-07-16
Abstract: Background: The objective of this study was to determine the duration of Sacituzumab Govitecan-hziy (SG) treatment in patients with Metastatic Triple-Negative Breast Cancer (mTNBC) stratified by granulocyte colony-stimulating factor (GCSF) treatment. Methods: This retrospective, observational… read more here.
Keywords: duration; breast cancer; treatment; gcsf ... See more keywords
Filgrastim Administered after Early Assessment Bone Marrow Biopsy during 7+3 Induction Therapy for Acute Myeloid Leukemia Reduces Length of Hospital Stay
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-131293
Abstract: Background National guidelines for acute myeloid leukemia (AML) therapy do not routinely recommend granulocyte colony stimulating factors (GCSF) during intensive induction therapy. Randomized trials have showed GCSF administration immediately after induction chemotherapy does improve time… read more here.
Keywords: recovery; gcsf; time; d14bm ... See more keywords
Use of granulocyte colony stimulating factor (GCSF) in patients receiving highly myelosuppressive chemotherapy for breast cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e21677
Abstract: e21677Background:We hypothesized that GCSF use may be suboptimal in the real world despite prior research that shows prophylaxis with GCSF can reduce neutropenic fevers and hospitalizations. Our aims were to characterize patterns of GCSF use… read more here.
Keywords: chemotherapy; gcsf; patients receiving; breast cancer ... See more keywords
In silico design of fusion toxin DT389GCSF and comparison of interaction it with GCSF receptor rather than DT486GCSF.
Sign Up to like & getrecommendations! Published in 2018 at "Current computer-aided drug design"
DOI: 10.2174/1573409914666181012151242
Abstract: BACKGROUND The negative effect of chemotherapy and radiotherapy on normal tissues as well as the high expense and length of these treatments have recently attracted researchers to the new methods that specifically affect cancerous tissues… read more here.
Keywords: protein; gcsf; fusion toxin; fusion ... See more keywords
Impact of PEG-GCSF in Breast Cancer Patients Undergoing Chemotherapy During the COVID-19 Pandemic: Single Center Experience and Literature Review
Sign Up to like & getrecommendations! Published in 2024 at "In Vivo"
DOI: 10.21873/invivo.13699
Abstract: Background/Aim: The COVID-19 pandemic brought many challenges in healthcare systems globally. Pegylated granulocyte colony stimulating factor (PEG-GCSF) is recommended to reduce febrile neutropenia (FN), however there are a few reports that G-CSF might worsen COVID-19… read more here.
Keywords: gcsf; breast cancer; peg gcsf; covid pandemic ... See more keywords