Rechallenge of denosumab in jaw osteonecrosis of patients with unresectable giant cell tumour of bone: a case series analysis and literature review
Sign Up to like & getrecommendations! Published in 2020 at "ESMO Open"
DOI: 10.1136/esmoopen-2019-000663
Abstract: Objectives Giant cell tumour of bone (GCTB) is a rare tumour, generally managed with surgery. Treatment of the very rare unresectable advanced/metastatic GCTB is challenging and denosumab is the only current available medical option, an… read more here.
Keywords: cell tumour; giant cell; tumour bone; denosumab ... See more keywords
Denosumab Enhances antitumour Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells.
Sign Up to like & getrecommendations! Published in 2025 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-24-1094
Abstract: Denosumab, a RANKL inhibitor, is primarily used to prevent osteoclastogenesis in the treatment of conditions such as osteoporosis, bone metastasis, and giant cell tumour of bone (GCTB). RANKL also plays an important role in immunity… read more here.
Keywords: gctb; denosumab; cell; cytotoxic ... See more keywords
Single-Cell RNA Sequencing Reveals the Migration of Osteoclasts in Giant Cell Tumor of Bone
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.715552
Abstract: Giant cell tumor of bone (GCTB) is benign tumor that can cause significant osteolysis and bone destruction at the epiphysis of long bones. Osteoclasts are thought to be highly associated with osteolysis in GCTB. However,… read more here.
Keywords: single cell; migration; migration osteoclasts; gctb ... See more keywords
Malignant Giant Cell Tumor of Bone: A Study of Clinical, Pathological, and Prognostic Profile from One Single Center
Sign Up to like & getrecommendations! Published in 2025 at "Bioengineering"
DOI: 10.3390/bioengineering12090911
Abstract: Malignant giant cell tumor of bone (GCTB) is a rare malignant bone tumor. This analysis was conducted on patients with malignant GCTB at our center. The clinical, demographic, and prognostic characteristics were evaluated and compared.… read more here.
Keywords: gctb; tumor; malignant giant; bone ... See more keywords
Prognostic Value and Quantitative CT Analysis in RANKL Expression of Spinal GCTB in the Denosumab Era: A Machine Learning Approach
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DOI: 10.3390/cancers14215201
Abstract: Simple Summary Prognostic assessment of giant cell tumor of bone (GCTB) is an ongoing challenge in the treatment and management of bone tumors. Recurrence rates of spinal GCTB are higher compared to GCTB in other… read more here.
Keywords: machine learning; rankl; analysis; gctb ... See more keywords
Progress on Denosumab Use in Giant Cell Tumor of Bone: Dose and Duration of Therapy
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DOI: 10.3390/cancers14235758
Abstract: Simple Summary Giant cell tumor of bone (GCTB) is an aggressive non-cancerous bone tumor. Surgery remains the main treatment for GCTB. Denosumab has been approved for the treatment of advanced or inoperable GCTB. The short-term… read more here.
Keywords: denosumab; bone; therapy; gctb ... See more keywords
Clinicopathological and histological analysis of secondary malignant giant cell tumors of bone without radiotherapy
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DOI: 10.3892/ol.2022.13439
Abstract: Giant cell tumor of bone (GCTB) is an intermediate bone tumor that rarely undergoes malignant transformation. Secondary malignant GCTB (SMGCTB) is defined as a lesion in which high-grade sarcoma occurs at the site of previously… read more here.
Keywords: secondary malignant; radiotherapy; giant cell; clinicopathological histological ... See more keywords
Efficacy and safety of denosumab de‑escalation in giant cell tumor of bone.
Sign Up to like & getrecommendations! Published in 2024 at "Oncology letters"
DOI: 10.3892/ol.2024.14520
Abstract: Giant cell tumor of bone (GCTB) is a locally aggressive intermediate bone tumor. Denosumab has shown effectiveness in GCTB treatment; however, the benefits of denosumab de-escalation for unresectable GCTB have not been well discussed. The… read more here.
Keywords: gctb; treatment; denosumab escalation; tumor ... See more keywords