Rationally Designed Monodisperse Gd2 O3 /Bi2 S3 Hybrid Nanodots for Efficient Cancer Theranostics.
Sign Up to like & getrecommendations! Published in 2018 at "Small"
DOI: 10.1002/smll.201802904
Abstract: Multifunctional nanotheranostic agents are of particular importance in the field of precise nanomedicine. However, a critical challenge remains in the rational fabrication of monodisperse multicomponent nanoparticles with enhanced multifunctional characteristics for efficient cancer theranostics. Here,… read more here.
Keywords: gd2; hybrid nanodots; monodisperse gd2; efficient cancer ... See more keywords
Easy synthesis of N-doped graphene by milling exfoliation with electrocatalytic activity towards the Oxygen Reduction Reaction (ORR)
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Hydrogen Energy"
DOI: 10.1016/j.ijhydene.2017.08.084
Abstract: Abstract We report a novel process to synthesize graphene (G) catalyst by mechanical milling using graphite flakes as the precursor. G sample has been doped ex situ with hydrazine as nitrogen source via solvothermal procedure… read more here.
Keywords: nitrogen; gd2; synthesis doped; doped graphene ... See more keywords
Manipulating clusters by regulating N,O chelating ligands: structures and multistep assembly mechanisms
Sign Up to like & getrecommendations! Published in 2020 at "CrystEngComm"
DOI: 10.1039/c9ce01730e
Abstract: We obtained a binuclear Gd(III) complex [Gd2(L1)2(NO3)4] (1, HL1 = (E)-2-(2-(pyridin-2-ylmethyleneamino)ethoxy)ethanol) by reacting N2O2-tetradentate chelating ligand HL1 with Gd(NO3)3·6H2O at solvothermal temperature of 100 °C. Time-dependent high-resolution electrospray ionization mass spectrometry (HRESI-MS) followed the formation… read more here.
Keywords: gd2; chelating ligands; manipulating clusters; clusters regulating ... See more keywords
First-line Anti-GD2 Therapy Combined With Consolidation Chemotherapy in 3 Patients With Newly Diagnosed Metastatic Ewing Sarcoma or Ewing-like Sarcoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000002488
Abstract: Despite multimodal therapy, the prognosis of patients with metastatic Ewing sarcoma (ES) remains poor, with new treatments urgently needed. The disialoganglioside GD2, a well-established tumor-associated antigen, is expressed in 40% to 90% of ES cells,… read more here.
Keywords: sarcoma; gd2; like sarcoma; metastatic ewing ... See more keywords
Anti-GD2 IgA kills tumors by neutrophils without antibody-associated pain in the preclinical treatment of high-risk neuroblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003163
Abstract: Background The addition of monoclonal antibody therapy against GD2 to the treatment of high-risk neuroblastoma led to improved responses in patients. Nevertheless, administration of GD2 antibodies against neuroblastoma is associated with therapy-limiting neuropathic pain. This… read more here.
Keywords: gd2; high risk; antibody; risk neuroblastoma ... See more keywords
Targeting disialoganglioside GD2 with chimeric antigen receptor-redirected T cells in lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003897
Abstract: Background We explored whether the disialoganglioside GD2 (GD2) is expressed in small cell lung cancer (SCLC) and non-SCLC (NSCLC) and can be targeted by GD2-specific chimeric antigen receptor (CAR) T cells. Methods GD2 expression was… read more here.
Keywords: car; gd2; cell; lung cancer ... See more keywords
Therapeutic efficacy of antibody-drug conjugates targeting GD2-positive tumors
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004646
Abstract: Background Both ganglioside GD2-targeted immunotherapy and antibody-drug conjugates (ADCs) have demonstrated clinical success as solid tumor therapies in recent years, yet no research has been carried out to develop anti-GD2 ADCs against solid tumors. This… read more here.
Keywords: gd2; drug conjugates; adcs; antibody drug ... See more keywords
Mechanism of effective combination radio-immunotherapy against 9464D-GD2, an immunologically cold murine neuroblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004834
Abstract: Background Most pediatric cancers are considered immunologically cold with relatively few responding to immune checkpoint inhibition. We recently described an effective combination radio-immunotherapy treatment regimen (combination adaptive-innate immunotherapy regimen (CAIR)) targeting adaptive and innate immunity… read more here.
Keywords: immunologically cold; mhc expression; immunotherapy; gd2 ... See more keywords
GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005187
Abstract: Background Aggressive primary brain tumors such as glioblastoma are uniquely challenging to treat. The intracranial location poses barriers to therapy, and the potential for severe toxicity. Effective treatments for primary brain tumors are limited, and… read more here.
Keywords: glioblastoma; gd2; brain; therapy ... See more keywords
Abstract 5115: Novel humanized anti-GD2 antibody inhibits GD2-mediated immunosuppression by targeting GD2+ breast cancer stem-like cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5115
Abstract: Background: Breast cancer stem-like cells (BCSCs) are reported to be a major contributing factor for tumor growth and chemotherapy resistance in triple-negative breast cancer (TNBC). We reported that the disialoganglioside GD2 is highly expressed on… read more here.
Keywords: cell; gd2; breast cancer; anti gd2 ... See more keywords
Abstract P6-02-01: Metabolic stress induces GD2 expression and cancer stem cell phenotype in triple negative breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs16-p6-02-01
Abstract: Breast cancer stem cells (BCSCs) have been characterized as a fraction of cells in primary tumors that are drug resistant and have metastatic potential. Ganglioside GD2 has been shown by us and others as a… read more here.
Keywords: cancer stem; gd2; metabolic stress; breast cancer ... See more keywords