Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas
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DOI: 10.1038/s41586-024-08171-9
Abstract: H3K27M-mutant diffuse midline gliomas (DMGs) express high levels of the disialoganglioside GD2 (ref. 1). Chimeric antigen receptor-modified T cells targeting GD2 (GD2-CART) eradicated DMGs in preclinical models1. Arm A of Phase I trial no. NCT04196413 (ref. 2) administered… read more here.
Keywords: gd2 cart; gd2; diffuse midline; midline gliomas ... See more keywords