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Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.10.038
Abstract: Converging evidence demonstrates an important role for gangliosides in brain function and neurodegenerative diseases. Exogenous GM1 is broadly neuroprotective, including in rodent, feline, and primate models of Parkinson's disease, and has shown positive effects in…
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Keywords:
gd3 synthase;
lentiviral mediated;
motor;
mptp induced ... See more keywords
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Published in 2017 at "Genes"
DOI: 10.1111/gbb.12377
Abstract: Parkinson's disease is a debilitating neurodegenerative condition for which there is no cure. Converging evidence implicates gangliosides in the pathogenesis of several neurodegenerative diseases, suggesting a potential new class of therapeutic targets. We have shown…
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Keywords:
gd3;
mice;
gd3 synthase;
targeted deletion ... See more keywords
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Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1076862
Abstract: Gangliosides are a large subfamily of glycosphingolipids that broadly exist in the nervous system and interact with signaling molecules in the lipid rafts. GD3 and GD2 are two types of disialogangliosides (GDs) that include two…
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Keywords:
gd3 gd2;
gd3 synthase;
role immunotherapy;
biological role ... See more keywords