Articles with "gd3 synthase" as a keyword



Lentiviral-mediated knock-down of GD3 synthase protects against MPTP-induced motor deficits and neurodegeneration

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Published in 2019 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2018.10.038

Abstract: Converging evidence demonstrates an important role for gangliosides in brain function and neurodegenerative diseases. Exogenous GM1 is broadly neuroprotective, including in rodent, feline, and primate models of Parkinson's disease, and has shown positive effects in… read more here.

Keywords: gd3 synthase; lentiviral mediated; motor; mptp induced ... See more keywords
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Targeted deletion of GD3 synthase protects against MPTPā€induced neurodegeneration

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Published in 2017 at "Genes"

DOI: 10.1111/gbb.12377

Abstract: Parkinson's disease is a debilitating neurodegenerative condition for which there is no cure. Converging evidence implicates gangliosides in the pathogenesis of several neurodegenerative diseases, suggesting a potential new class of therapeutic targets. We have shown… read more here.

Keywords: gd3; mice; gd3 synthase; targeted deletion ... See more keywords
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The biological role and immunotherapy of gangliosides and GD3 synthase in cancers

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Published in 2023 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2023.1076862

Abstract: Gangliosides are a large subfamily of glycosphingolipids that broadly exist in the nervous system and interact with signaling molecules in the lipid rafts. GD3 and GD2 are two types of disialogangliosides (GDs) that include two… read more here.

Keywords: gd3 gd2; gd3 synthase; role immunotherapy; biological role ... See more keywords