Lentiviral-mediated knock-down of GD3 synthase protects against MPTP-induced motor deficits and neurodegeneration
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.10.038
Abstract: Converging evidence demonstrates an important role for gangliosides in brain function and neurodegenerative diseases. Exogenous GM1 is broadly neuroprotective, including in rodent, feline, and primate models of Parkinson's disease, and has shown positive effects in… read more here.
Keywords: gd3 synthase; lentiviral mediated; motor; mptp induced ... See more keywords
Gene Therapy Targeting GD3 Synthase Protects Against MPTP‐Induced Parkinsonism and Executive Dysfunction
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.70061
Abstract: More than half of Parkinson's patients exhibit fronto‐striatally mediated executive dysfunction, including deficits in sustained attention, judgment, and impulse control. We have previously shown that modification of brain gangliosides by targeted deletion of GD3 synthase… read more here.
Keywords: control; impulse control; executive dysfunction; gd3 synthase ... See more keywords
Targeted deletion of GD3 synthase protects against MPTP‐induced neurodegeneration
Sign Up to like & getrecommendations! Published in 2017 at "Genes"
DOI: 10.1111/gbb.12377
Abstract: Parkinson's disease is a debilitating neurodegenerative condition for which there is no cure. Converging evidence implicates gangliosides in the pathogenesis of several neurodegenerative diseases, suggesting a potential new class of therapeutic targets. We have shown… read more here.
Keywords: gd3; mice; gd3 synthase; targeted deletion ... See more keywords
The biological role and immunotherapy of gangliosides and GD3 synthase in cancers
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1076862
Abstract: Gangliosides are a large subfamily of glycosphingolipids that broadly exist in the nervous system and interact with signaling molecules in the lipid rafts. GD3 and GD2 are two types of disialogangliosides (GDs) that include two… read more here.
Keywords: gd3 gd2; gd3 synthase; role immunotherapy; biological role ... See more keywords