GD3 synthase drives resistance to p53-induced apoptosis in breast cancer by modulating mitochondrial function
Sign Up to like & getrecommendations! Published in 2025 at "Oncogene"
DOI: 10.1038/s41388-025-03432-x
Abstract: TP53 mutations are common in breast cancer (BC) and are associated with poor prognosis. GD3 synthase (GD3S/ST8SIA1), a gene associated with breast cancer stem cells, is upregulated in tumors with p53 mutations. However, the functional… read more here.
Keywords: gd3s; breast cancer; p53 mutations; p53 ... See more keywords
Abstract PO2-24-08: GD3 Synthase is a Master Regulator of Wild-Type p53–Mediated Apoptosis and Mutant p53–Mediated Tumorigenesis
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs23-po2-24-08
Abstract: The tumor suppressor protein p53 is essential for maintaining genomic stability and regulating cellular responses to stress. TP53 mutations are common in breast cancer (BC) and other malignancies. We previously showed that ganglioside GD2 identifies… read more here.
Keywords: gd3s; p53 mutations; p53; p53 mediated ... See more keywords