GDF11 restricts aberrant lipogenesis and changes in mitochondrial structure and function in human hepatocellular carcinoma cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30151
Abstract: Growth differentiation factor 11 (GDF11) has been characterized as a key regulator of differentiation in cells that retain stemness features. Recently, it has been reported that GDF11 exerts tumor‐suppressive properties in hepatocellular carcinoma cells, decreasing… read more here.
Keywords: hepatocellular carcinoma; gdf11 restricts; carcinoma cells; gdf11 ... See more keywords
Targeted Approach to Distinguish and Determine Absolute Levels of GDF8 and GDF11 in Mouse Serum
Sign Up to like & getrecommendations! Published in 2020 at "PROTEOMICS"
DOI: 10.1002/pmic.201900104
Abstract: Growth differentiation factor 11 (GDF11) is a TGF‐β superfamily circulating factor that regulates cardiomyocyte size in rodents, sharing 90% amino acid sequence identity in the active domains with myostatin (GDF8)—the major determinant of skeletal muscle… read more here.
Keywords: targeted approach; approach distinguish; gdf11; mouse serum ... See more keywords
Exogenous GDF11 induces cardiac and skeletal muscle dysfunction and wasting
Sign Up to like & getrecommendations! Published in 2017 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-017-0639-9
Abstract: Growth differentiation factor 11 (GDF11), a TGF-beta superfamily member, is highly homologous to myostatin and essential for embryonic patterning and organogenesis. Reports of GDF11 effects on adult tissues are conflicting, with some describing anti-aging and… read more here.
Keywords: skeletal muscle; muscle; dysfunction; cardiac skeletal ... See more keywords
Exogenous GDF11 attenuates non-canonical TGF-β signaling to protect the heart from acute myocardial ischemia–reperfusion injury
Sign Up to like & getrecommendations! Published in 2019 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-019-0728-z
Abstract: Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor beta 1 (TGF-β1) superfamily that reverses age-related cardiac hypertrophy, improves muscle regeneration and angiogenesis, and maintains progenitor cells in injured tissue. Recently,… read more here.
Keywords: heart; reperfusion; gdf11; injury ... See more keywords
Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental cell"
DOI: 10.1016/j.devcel.2017.10.027
Abstract: Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous carcinoma in which various tumor-suppressor genes are lost by mutation, deletion, or silencing. Here we report a tumor-suppressive mode of action for growth-differentiation factor 11 (GDF11)… read more here.
Keywords: tumor suppressor; gdf11; cancer; triple negative ... See more keywords
Tail Bud Progenitor Activity Relies on a Network Comprising Gdf11, Lin28, and Hox13 Genes.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2018.12.004
Abstract: During the trunk-to-tail transition, axial progenitors relocate from the epiblast to the tail bud. Here, we show that this process entails a major regulatory switch, bringing tail bud progenitors under Gdf11 signaling control. Gdf11 mutant… read more here.
Keywords: tail bud; progenitor; activity; gdf11 ... See more keywords
GDF11 replenishment protects against hypoxia-mediated apoptosis in cardiomyocytes by regulating autophagy.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173495
Abstract: GDF11 has been reported to play a critical role in rejuvenating hypertrophy heart, skeletal muscle, and blood vessel regeneration in aged mice. Whether GDF11 can regulate autophagy in cardiomyocytes remains largely unknown. Thus, the purpose… read more here.
Keywords: replenishment protects; apoptosis cardiomyocytes; gdf11 replenishment; apoptosis ... See more keywords
A Prodomain Fragment from the Proteolytic Activation of Growth Differentiation Factor 11 Remains Associated with the Mature Growth Factor and Keeps It Soluble.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b00302
Abstract: Growth differentiation factor 11 (GDF11), a member of the transforming growth factor β (TGF-β) family, plays diverse roles in mammalian development. It is synthesized as a large, inactive precursor protein containing a prodomain, pro-GDF11, and… read more here.
Keywords: mature; factor; growth factor; gdf11 ... See more keywords
The role of GDF11 in aging and skeletal muscle, cardiac and bone homeostasis
Sign Up to like & getrecommendations! Published in 2019 at "Critical Reviews in Biochemistry and Molecular Biology"
DOI: 10.1080/10409238.2019.1610722
Abstract: Abstract GDF11 is a secreted factor in the TGFß family of cytokines. Its nearest neighbor evolutionarily is myostatin, a factor discovered as being a negative regulator of skeletal muscle growth. High profile studies several years… read more here.
Keywords: skeletal muscle; aging skeletal; bone; biology ... See more keywords
GDF11 Is a Novel Protective Factor Against Vascular Calcification
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000001357
Abstract: Supplemental Digital Content is Available in the Text. Abstract: Vascular calcification (VC) occurs via an active cell-mediated process, which involves osteogenic differentiation, apoptosis, and phenotypic transformation of vascular smooth muscle cells (VSMCs). As a member… read more here.
Keywords: calcification; gdf11; osteogenic differentiation; factor ... See more keywords
Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy
Sign Up to like & getrecommendations! Published in 2021 at "Aging Cell"
DOI: 10.1111/acel.13532
Abstract: The “rejuvenating” effect of growth differentiation factor 11 (GDF11) is called into question recently, and its role, as well as plausible signaling mechanisms in liver senescence, is unclear. To overexpress or knockdown GDF11, aged male… read more here.
Keywords: autophagic flux; growth differentiation; senescence; factor ... See more keywords