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Published in 2020 at "ESC Heart Failure"
DOI: 10.1002/ehf2.12728
Abstract: Heart failure is a growing health issue as a negative consequence of improved survival upon myocardial infarction, unhealthy lifestyle, and the ageing of our population. The large and complex pathology underlying heart failure makes diagnosis…
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Keywords:
heart;
gdf15;
heart failure;
factor ... See more keywords
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Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109501
Abstract: Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) activates AMP-activated protein kinase (AMPK) and plays a crucial role in glucose and lipid metabolism. Here, we examine whether PPARβ/δ activation effects depend on growth differentiation factor 15 (GDF15), a…
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Keywords:
effects ppar;
gdf15;
ampk;
activation ... See more keywords
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Published in 2019 at "Cell Metabolism"
DOI: 10.1016/j.cmet.2018.12.016
Abstract: Summary GDF15 is an established biomarker of cellular stress. The fact that it signals via a specific hindbrain receptor, GFRAL, and that mice lacking GDF15 manifest diet-induced obesity suggest that GDF15 may play a physiological…
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Keywords:
nutritional stress;
gdf15 provides;
gdf15;
stress ... See more keywords
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Published in 2020 at "Osteoarthritis and Cartilage"
DOI: 10.1016/j.joca.2020.02.196
Abstract: s / Osteoarthritis and Cartilage 28 (2020) S86eS527 S120 EVs from the two autologous blood derived products PRP and the cell free alternative hyperacute (hypACT) serum in an inflammation model was investigated. Methods: PRP and…
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Keywords:
production;
osteoarthritis;
gdf15;
evs ... See more keywords
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Published in 2022 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2022.111643
Abstract: The loss of functional insulin-producing β-cells is a hallmark of type 1 diabetes mellitus (T1DM). Previously, we reported that the non-steroidal anti-inflammatory drug activated gene-1, or growth differentiation factor-15 (NAG-1/GDF15) inhibits obesity and improves insulin…
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Keywords:
gdf15;
stz;
type diabetes;
nag gdf15 ... See more keywords
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Published in 2019 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2019.01.003
Abstract: Objective Analogues of GDF15 (Growth Differentiation Factor 15) are promising new anti-obesity therapies as pharmacological treatment with GDF15 results in dramatic reductions of food intake and body weight. GDF15 exerts its central anorexic effects by…
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Keywords:
mice;
food intake;
weight loss;
gdf15 ... See more keywords
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Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c00571
Abstract: M2 macrophages are generally recognized to have a protumor role, while the effect of M1 macrophages in cancer is controversial. Here, the in vitro and in vivo effects of conditioned medium from M1 macrophages (M1-CM)…
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Keywords:
erbb2 phosphorylation;
oral squamous;
gdf15;
invasion ... See more keywords
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Published in 2017 at "Nature Medicine"
DOI: 10.1038/nm.4394
Abstract: Growth differentiation factor 15 (GDF15; also known as MIC-1) is a divergent member of the TGF-β superfamily and is associated with body-weight regulation in humans and rodents. However, the cognate receptor of GDF15 is unknown.…
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Keywords:
receptor gdf15;
anti obesity;
food intake;
gdf15 ... See more keywords
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Published in 2020 at "Nature Medicine"
DOI: 10.1038/s41591-020-0945-x
Abstract: Cancer cachexia is a highly prevalent condition associated with poor quality of life and reduced survival 1 . Tumor-induced perturbations in the endocrine, immune and nervous systems drive anorexia and catabolic changes in adipose tissue…
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Keywords:
gdf15;
mice;
cancer cachexia;
cancer ... See more keywords
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Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-56922-w
Abstract: Physical activity is an important contributor to muscle adaptation and metabolic health. Growth differentiation factor 15 (GDF15) is established as cellular and nutritional stress-induced cytokine but its physiological role in response to active lifestyle or…
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Keywords:
muscle;
gdf15;
mice;
acute exercise ... See more keywords
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Published in 2018 at "Geburtshilfe und Frauenheilkunde"
DOI: 10.1055/a-0661-0287
Abstract: Introduction Hyperemesis gravidarum (HG), a pregnancy complication characterized by severe nausea and vomiting in pregnancy, occurs in up to 2% of pregnancies. It is associated with both maternal and fetal morbidity. HG is highly heritable…
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Keywords:
familial recurrent;
recurrent;
gdf15;
hyperemesis gravidarum ... See more keywords