Growth differentiation factor 15 in adverse cardiac remodelling: from biomarker to causal player
Sign Up to like & getrecommendations! Published in 2020 at "ESC Heart Failure"
DOI: 10.1002/ehf2.12728
Abstract: Heart failure is a growing health issue as a negative consequence of improved survival upon myocardial infarction, unhealthy lifestyle, and the ageing of our population. The large and complex pathology underlying heart failure makes diagnosis… read more here.
Keywords: heart; gdf15; heart failure; factor ... See more keywords
GDF15 activates human fibroblast MRC5 cells via miR-338/STAT1 in silicosis
Sign Up to like & getrecommendations! Published in 2025 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-025-01627-w
Abstract: Growth differentiation factor 15 (GDF-15) has been implicated in multiple biological functions. However, the role of GDF15 in silicosis remains unclear. In this study, the serum level of GDF-15 was investigated in 46 patients with… read more here.
Keywords: mir 338; mrc5 cells; gdf15; expression ... See more keywords
GDF15 attenuates myocardial hypoxic injury by inhibiting mitochondrial damage through BNIP3 pathway
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Biology Reports"
DOI: 10.1007/s11033-025-10824-5
Abstract: Growth differentiation factor 15 (GDF15), a hypoxia-responsive mediator in myocardial injury, is established as a mitochondrial stress biomarker in skeletal muscle. However, its mechanistic role in regulating mitophagy during cardiac hypoxia remains unknown. In this… read more here.
Keywords: hypoxic injury; gdf15; hypoxia; injury ... See more keywords
GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109501
Abstract: Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) activates AMP-activated protein kinase (AMPK) and plays a crucial role in glucose and lipid metabolism. Here, we examine whether PPARβ/δ activation effects depend on growth differentiation factor 15 (GDF15), a… read more here.
Keywords: effects ppar; gdf15; ampk; activation ... See more keywords
GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans
Sign Up to like & getrecommendations! Published in 2019 at "Cell Metabolism"
DOI: 10.1016/j.cmet.2018.12.016
Abstract: Summary GDF15 is an established biomarker of cellular stress. The fact that it signals via a specific hindbrain receptor, GFRAL, and that mice lacking GDF15 manifest diet-induced obesity suggest that GDF15 may play a physiological… read more here.
Keywords: nutritional stress; gdf15 provides; gdf15; stress ... See more keywords
Boswellia serrata extract and curcumin increase GDF15 production by human primary osteoarthritis chondrocytes: a new mechanism of action
Sign Up to like & getrecommendations! Published in 2020 at "Osteoarthritis and Cartilage"
DOI: 10.1016/j.joca.2020.02.196
Abstract: s / Osteoarthritis and Cartilage 28 (2020) S86eS527 S120 EVs from the two autologous blood derived products PRP and the cell free alternative hyperacute (hypACT) serum in an inflammation model was investigated. Methods: PRP and… read more here.
Keywords: production; osteoarthritis; gdf15; evs ... See more keywords
NAG-1/GDF15 protects against streptozotocin-induced type 1 diabetes by inhibiting apoptosis, preserving beta-cell function, and suppressing inflammation in pancreatic islets
Sign Up to like & getrecommendations! Published in 2022 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2022.111643
Abstract: The loss of functional insulin-producing β-cells is a hallmark of type 1 diabetes mellitus (T1DM). Previously, we reported that the non-steroidal anti-inflammatory drug activated gene-1, or growth differentiation factor-15 (NAG-1/GDF15) inhibits obesity and improves insulin… read more here.
Keywords: gdf15; stz; type diabetes; nag gdf15 ... See more keywords
GDF15 acts synergistically with liraglutide but is not necessary for the weight loss induced by bariatric surgery in mice
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2019.01.003
Abstract: Objective Analogues of GDF15 (Growth Differentiation Factor 15) are promising new anti-obesity therapies as pharmacological treatment with GDF15 results in dramatic reductions of food intake and body weight. GDF15 exerts its central anorexic effects by… read more here.
Keywords: mice; food intake; weight loss; gdf15 ... See more keywords
M1 Macrophages Enhance Survival and Invasion of Oral Squamous Cell Carcinoma by Inducing GDF15-Mediated ErbB2 Phosphorylation
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c00571
Abstract: M2 macrophages are generally recognized to have a protumor role, while the effect of M1 macrophages in cancer is controversial. Here, the in vitro and in vivo effects of conditioned medium from M1 macrophages (M1-CM)… read more here.
Keywords: erbb2 phosphorylation; oral squamous; gdf15; invasion ... See more keywords
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand
Sign Up to like & getrecommendations! Published in 2017 at "Nature Medicine"
DOI: 10.1038/nm.4394
Abstract: Growth differentiation factor 15 (GDF15; also known as MIC-1) is a divergent member of the TGF-β superfamily and is associated with body-weight regulation in humans and rodents. However, the cognate receptor of GDF15 is unknown.… read more here.
Keywords: receptor gdf15; anti obesity; food intake; gdf15 ... See more keywords
Elevated plasma GDF15 combined with FGF21 suggests mitochondrial dysfunction in a subgroup of anorexia nervosa patients
Sign Up to like & getrecommendations! Published in 2025 at "Translational Psychiatry"
DOI: 10.1038/s41398-025-03425-0
Abstract: Growth and differentiation factor 15 (GDF15) is a significant player in cellular stress and energy homeostasis. GDF15 is elevated in cancer cachexia, chemotherapy-induced anorexia, hyperemesis gravidarum, and mitochondrial disorders. Here we analyze GDF15 in anorexia… read more here.
Keywords: gdf15; plasma gdf15; high gdf15; mitochondrial dysfunction ... See more keywords