Immunochromatographic test and ELISA for the detection of glutamate dehydrogenase (GDH) and A/B toxins as an alternative for the diagnosis of Clostridioides (Clostridium) difficile–associated diarrhea in foals and neonatal piglets
Sign Up to like & getrecommendations! Published in 2020 at "Brazilian Journal of Microbiology"
DOI: 10.1007/s42770-020-00275-4
Abstract: Considering the lack of studies evaluating the performance of commercially available methods for diagnosis of Clostridioides ( Clostridium ) difficile infection (CDI) in animals, the present study aimed to assess an immunochromatographic test for detection… read more here.
Keywords: flow test; detection; gdh; test ... See more keywords
Performance of laboratory tests for detection for Clostridioides difficile: A multicenter prospective study in Japan.
Sign Up to like & getrecommendations! Published in 2019 at "Anaerobe"
DOI: 10.1016/j.anaerobe.2019.102107
Abstract: BACKGROUND The optimal and practical laboratory diagnostic approach for detection of Clostridioides difficile to aid in the diagnosis of C. difficile infection (CDI) is controversial. A two-step algorithm with initial detection of glutamate dehydrogenase (GDH)… read more here.
Keywords: detection; gdh; detection clostridioides; clostridioides difficile ... See more keywords
GDH and toxin immunoassay for the diagnosis of Clostridioides (Clostridium) difficile infection is not a 'one size fit all' screening test.
Sign Up to like & getrecommendations! Published in 2019 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2018.12.010
Abstract: Diagnosing Clostridioides (Clostridium) difficile infection is challenged by lack of a clear gold standard. We sought to determine if the two-step algorithm (screening GDH and toxin lateral flow assay followed by tcdB PCR) would have… read more here.
Keywords: clostridium difficile; gdh; clostridioides clostridium; gdh toxin ... See more keywords
Administration of chitosan-tripolyphosphate-DNA nanoparticles to knockdown glutamate dehydrogenase expression impairs transdeamination and gluconeogenesis in the liver.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2018.09.002
Abstract: Glutamate dehydrogenase (GDH) plays a major role in amino acid catabolism. To increase the current knowledge of GDH function, we analysed the effect of GDH silencing on liver intermediary metabolism from gilthead sea bream (Sparus… read more here.
Keywords: dehydrogenase; gdh; chitosan tripolyphosphate; administration chitosan ... See more keywords
Stereoselective synthesis of a key chiral intermediate of (S)-Rivastigmine by AKR-GDH recombinant whole cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2018.11.016
Abstract: Herein, three aldo/ketoreductases (AKRs) were obtained and used to prepare N- ethyl-methyl-carbamic acid-3-[(1S)-hydroxy-ethyl]-phenyl ester ((S)-NEMCA-HEPE), which is a key intermediate of (S)-Rivastigmine. To avoid the usage of extra cofactors, the recombinant whole-cells containing AKRs and… read more here.
Keywords: gdh; reaction; recombinant whole; intermediate rivastigmine ... See more keywords
Glutamate dehydrogenase is essential in the acclimation of Virgilia divaricata, a legume indigenous to the nutrient-poor Mediterranean-type ecosystems of the Cape Fynbos.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of plant physiology"
DOI: 10.1016/j.jplph.2019.153053
Abstract: Glutamate dehydrogenase (NAD(H)- GDH, EC 1.4.1.2) is an important enzyme in nitrogen (N) metabolism. It serves as a link between C and N metabolism, in its role of assimilating ammonia into glutamine or deaminating glutamate… read more here.
Keywords: gdh; divaricata legume; virgilia divaricata; mediterranean type ... See more keywords
Ammonium removal by erythrocyte-bioreactors based on glutamate dehydrogenase from Proteus sp. jointly with porcine heart alanine aminotransferase
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-09435-y
Abstract: Excessive ammonium blood concentration causes many serious neurological complications. The medications currently used are not very effective. To remove ammonium from the blood, erythrocyte-bioreactors containing enzymes that processing ammonium have been proposed. The most promising… read more here.
Keywords: proteus; ammonium removal; gdh; erythrocyte bioreactors ... See more keywords
The effects of fullerene on photosynthetic apparatus, chloroplast-encoded gene expression and nitrogen assimilation in Zea mays under cobalt stress.
Sign Up to like & getrecommendations! Published in 2022 at "Physiologia plantarum"
DOI: 10.1111/ppl.13720
Abstract: Carbon nanostructures, such as the water-soluble fullerene (FLN) derivatives, are considered perspective agents for agriculture. FLN can be a novel nano-agent modulating plant response against stress conditions. However, the mechanism underlying the impacts of FLN… read more here.
Keywords: gdh; stress; cobalt stress; assimilation ... See more keywords
Glutamate dehydrogenase from Pantoea ananatis: A new bacterial enzyme with dual coenzyme specificity
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DOI: 10.1371/journal.pone.0328289
Abstract: Glutamate dehydrogenase (GDH) catalyzes the reversible conversion of α-ketoglutarate (α-KG) to L-glutamate (Glu) and plays an important role in linking nitrogen and carbon metabolism. However, little is known about this enzyme in the biotechnologically important… read more here.
Keywords: glutamate dehydrogenase; specificity; pantoea ananatis; glutamate ... See more keywords
Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.646291
Abstract: Impaired liver function may lead to hyperammonemia and risk for hepatic encephalopathy. In brain, detoxification of ammonia is mediated mainly by glutamine synthetase (GS) in astrocytes. This requires a continuous de novo synthesis of glutamate,… read more here.
Keywords: gdh; hyperammonemia; glutamate; ammonia ... See more keywords
Case Report: Clinical impact of BRCA1 and BRIP1 vs. BRCA1 and BRCA2 germline double heterozygosity in ovarian cancer: a comparative case study
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2025.1614373
Abstract: Ovarian cancer (OC) is a highly heterogeneous malignancy influenced by germline genetic factors, with BRCA1/2 mutations being well-established risk factors. Germline double heterozygosity (GDH), particularly involving rare combinations, remains poorly understood. This study presents the… read more here.
Keywords: brca1; ovarian cancer; brca1 brip1; case ... See more keywords