Assessment of Limitations to Optimization of Guideline-Directed Medical Therapy in Heart Failure From the GUIDE-IT Trial: A Secondary Analysis of a Randomized Clinical Trial.
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DOI: 10.1001/jamacardio.2020.0640
Abstract: Importance Despite evidence that guideline-directed medical therapy (GDMT) improves outcomes in patients with heart failure (HF) and reduced ejection fraction, many patients are undertreated. The Guiding Evidence-Based Therapy Using Biomarker Intensified Treatment (GUIDE-IT) trial tested… read more here.
Keywords: trial; guideline directed; analysis; medical therapy ... See more keywords
Guideline-directed Medical Therapy May Not Be Harmful In Patients with Transthyretin Cardiac Amyloidosis and Heart Failure with Reduced Ejection Fraction
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DOI: 10.1016/j.cardfail.2020.09.372
Abstract: Introduction No guidelines exist on the use of guideline-directed medical therapy (GDMT) in the setting of transthyretin cardiac amyloidosis (TTR CA) and HFrEF, and its use remains controversial. There is no survival data demonstrating the… read more here.
Keywords: gdmt; ttr hfref; may harmful; directed medical ... See more keywords
Medication Trajectory and Treatment Patterns in Medicare Patients With Heart Failure and Reduced Ejection Fraction.
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DOI: 10.1016/j.cardfail.2021.11.013
Abstract: BACKGROUND Although a worsening heart failure event (WHFE) is associated with poor outcomes in patients with heart failure with reduced ejection fraction (HFrEF), it is unclear how guideline-directed medical therapy (GDMT) is used in this… read more here.
Keywords: without whfes; failure; gdmt; treatment ... See more keywords
Guideline-directed medical therapy after transcatheter edge-to-edge mitral valve repair
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DOI: 10.1136/heartjnl-2022-320826
Abstract: Objective A sizeable proportion of patients with secondary mitral regurgitation (SMR) do not receive guideline-directed medical therapy (GDMT) for heart failure (HF). We investigated the association between the use of GDMT and mortality in patients… read more here.
Keywords: teer; therapy; mortality; gdmt ... See more keywords
Abstract MP71: Socioeconomic Status, Guideline Directed Medical Therapy, and Prognosis in Heart Failure With Reduced Ejection Fraction: The Atherosclerosis Risk in Community (ARIC) Study
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DOI: 10.1161/circ.141.suppl_1.mp71
Abstract: Introduction: Current research suggests racial differences exist in the utilization of guideline directed medical therapy (GDMT) and prognosis in heart failure with reduced ejection fraction (HFrEF). Whether individual and community level socioeconomic status (SES) impacts… read more here.
Keywords: guideline directed; prognosis; prognosis heart; medical therapy ... See more keywords