Complementation of dopaminergic signaling by Pitx3–GDNF synergy induces dopamine secretion by multipotent Ntera2 cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29109
Abstract: Human teratocarcinoma cell line Ntera2 (NT2) expresses dopamine signals and has shown its safe profile for clinical applications. Attempts to restore complete dopaminergic (DAergic) phenotype enabling these cells to secrete dopamine have not been fully… read more here.
Keywords: complementation dopaminergic; gdnf; nt2 cells; pitx3 gdnf ... See more keywords
Transposon-mediated glial cell line-derived neurotrophic factor overexpression in human adipose tissue-derived mesenchymal stromal cells: A potential approach for neuroregenerative medicine?
Sign Up to like & getrecommendations! Published in 2022 at "Journal of tissue engineering and regenerative medicine"
DOI: 10.1002/term.3296
Abstract: Glial cell line-derived neurotrophic factor (GDNF) has neuroprotective effects and may be a promising candidate for regenerative strategies focusing on neurodegenerative diseases. As GDNF cannot cross the blood-brain barrier to potentially regenerate damaged brain areas,… read more here.
Keywords: tissue derived; medicine; overexpression; adipose tissue ... See more keywords
Impact of Auditory Integration Therapy (AIT) on the Plasma Levels of Human Glial Cell Line–Derived Neurotrophic Factor (GDNF) in Autism Spectrum Disorder
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-019-01332-w
Abstract: Neurotrophic factors, including the glial cell line–derived neurotrophic factor (GDNF), are of importance for synaptic plasticity regulation, intended as the synapses’ ability to strengthen or weaken their responses to differences in neuronal activity. Such plasticity… read more here.
Keywords: plasma; cell line; gdnf; autism ... See more keywords
MES23.5 DA Immortalized Neuroblastoma Cells Self-protect Against Early Injury by Overexpressing Glial Cell–derived Neurotrophic Factor via Akt1/Eya1/Six2 Signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-019-01416-7
Abstract: Injured neurons can initiate their own neurotoxin-induced repair mechanisms by expressing protective genes and activating specific intracellular signal transduction pathways. Although glial cell–derived neurotrophic factor (GDNF) plays a key role in the repair of dopaminergic… read more here.
Keywords: overexpression; cell; gdnf; factor ... See more keywords
Adenoviral Vector Delivery of vegf, Angiogenin, and gdnf Genes Promotes Angiogenesis in Ischemic Skeletal Muscle
Sign Up to like & getrecommendations! Published in 2020 at "BioNanoScience"
DOI: 10.1007/s12668-019-00688-y
Abstract: Effects of adenoviruses carrying genes of a vascular endothelial growth factor ( vegf 165 ), a glial-cell derived neurotrophic factor ( gdnf ), and angiogenin ( ang ) were studied in a rat model of… read more here.
Keywords: ad5 ang; vegf; ad5; gdnf ... See more keywords
Pandemrix-induced narcolepsy is associated with genes related to immunity and neuronal survival
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.01.041
Abstract: Background The incidence of narcolepsy rose sharply after the swine influenza A (H1N1) vaccination campaign with Pandemrix. Narcolepsy is an immune-related disorder with excessive daytime sleepiness. The most frequent form is strongly associated with HLA-DQB1*06:02,… read more here.
Keywords: pandemrix induced; gdnf; narcolepsy associated; induced narcolepsy ... See more keywords
Encapsulated cell device approach for combined electrical stimulation and neurotrophic treatment of the deaf cochlea
Sign Up to like & getrecommendations! Published in 2017 at "Hearing Research"
DOI: 10.1016/j.heares.2017.04.013
Abstract: Abstract Profound hearing impairment can be overcome by electrical stimulation (ES) of spiral ganglion neurons (SGNs) via a cochlear implant (CI). Thus, SGN survival is critical for CI efficacy. Application of glial cell line‐derived neurotrophic… read more here.
Keywords: gdnf; stimulation; treatment; neurotrophic treatment ... See more keywords
An analysis of the rewarding and aversive associative properties of nicotine in the neonatal quinpirole model: Effects on glial cell line-derived neurotrophic factor (GDNF)
Sign Up to like & getrecommendations! Published in 2018 at "Schizophrenia Research"
DOI: 10.1016/j.schres.2017.03.024
Abstract: This study analyzed the associative properties of nicotine in a conditioned place preference (CPP) paradigm in adolescent rats neonatally treated with quinpirole (NQ) or saline (NS). NQ produces dopamine D2 receptor supersensitivity that persists throughout… read more here.
Keywords: cell line; experiment; gdnf; glial cell ... See more keywords
Cross-platform single cell analysis of kidney development shows stromal cells express Gdnf.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental biology"
DOI: 10.1016/j.ydbio.2017.11.006
Abstract: The developing kidney provides a useful model for study of the principles of organogenesis. In this report we use three independent platforms, Drop-Seq, Chromium 10x Genomics and Fluidigm C1, to carry out single cell RNA-Seq… read more here.
Keywords: single cell; gdnf; analysis; stromal cells ... See more keywords
Development of the urogenital system is regulated via the 3′UTR of GDNF
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-40457-1
Abstract: Mechanisms controlling ureter lenght and the position of the kidney are poorly understood. Glial cell-line derived neurotrophic factor (GDNF) induced RET signaling is critical for ureteric bud outgrowth, but the function of endogenous GDNF in… read more here.
Keywords: urogenital system; development urogenital; utr gdnf; gdnf ... See more keywords
Glial-derived neurotrophic factor is essential for blood-nerve barrier functional recovery in an experimental murine model of traumatic peripheral neuropathy
Sign Up to like & getrecommendations! Published in 2018 at "Tissue Barriers"
DOI: 10.1080/21688370.2018.1479570
Abstract: ABSTRACT There is emerging evidence that glial-derived neurotrophic factor (GDNF) is a potent inducer of restrictive barrier function in tight junction-forming microvascular endothelium and epithelium, including the human blood-nerve barrier (BNB) in vitro. We sought… read more here.
Keywords: derived neurotrophic; microscopy; gdnf; neurotrophic factor ... See more keywords