Down-Regulated CUEDC2 Increases GDNF Expression by Stabilizing CREB Through Reducing Its Ubiquitination in Glioma.
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemical research"
DOI: 10.1007/s11064-020-03140-w
Abstract: Abnormally high expression of glial cell line-derived neurotrophic factor (GDNF) derived from glioma cells has essential impacts on gliomagenesis and development, but the molecular basis underlying increased GDNF expression in glioma cells remain unclear. This work… read more here.
Keywords: glioma; creb; expression; glioma cells ... See more keywords
GDNF-mediated rescue of the nigrostriatal system depends on the degree of degeneration
Sign Up to like & getrecommendations! Published in 2018 at "Gene Therapy"
DOI: 10.1038/s41434-018-0049-0
Abstract: Glial cell-line derived neurotrophic factor (GDNF) is a promising therapeutic molecule to treat Parkinson’s disease. Despite an excellent profile in experimental settings, clinical trials testing GDNF have failed. One of the theories to explain these… read more here.
Keywords: gdnf expression; nigrostriatal system; degeneration; nigrostriatal degeneration ... See more keywords