Nuclear export restricts Gdown1 to a mitotic function
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac015
Abstract: Abstract Approximately half of purified mammalian RNA polymerase II (Pol II) is associated with a tightly interacting sub-stoichiometric subunit, Gdown1. Previous studies have established that Gdown1 inhibits transcription initiation through competitive interactions with general transcription… read more here.
Keywords: gdown1; function; nuclear export; export restricts ... See more keywords
Overcoming the cytoplasmic retention of GDOWN1 modulates global transcription and facilitates stress adaptation
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.79116
Abstract: Dynamic regulation of transcription is crucial for the cellular responses to various environmental or developmental cues. Gdown1 is a ubiquitously expressed, RNA polymerase II (Pol II) interacting protein, essential for the embryonic development of metazoan.… read more here.
Keywords: transcription; global transcription; gdown1; stress adaptation ... See more keywords