Pathogenic Variants in Fucokinase Cause a Congenital Disorder of Glycosylation.
Sign Up to like & getrecommendations! Published in 2018 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2018.10.021
Abstract: FUK encodes fucokinase, the only enzyme capable of converting L-fucose to fucose-1-phosphate, which will ultimately be used for synthesizing GDP-fucose, the donor substrate for all fucosyltransferases. Although it is essential for fucose salvage, this pathway… read more here.
Keywords: pathogenic variants; disorder; cause congenital; glycosylation ... See more keywords
One-pot synthesis of GDP-l-fucose by a four-enzyme cascade expressed in Lactococcus lactis.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2017.10.009
Abstract: GDP-l-fucose is an l-fucose donor to synthesize fucosylated compounds such as human milk oligosaccharides or Lewis antigen. In this study, we used Lactococcus lactis subsp. cremoris NZ9000 to express 4 enzymes, ManB, ManC, Gmd, and… read more here.
Keywords: lactis; pot synthesis; gmd wcag; one pot ... See more keywords
Strategies for Enhancing Microbial Production of 2'-Fucosyllactose, the Most Abundant Human Milk Oligosaccharide.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c04539
Abstract: Human milk oligosaccharides (HMOs), a group of structurally diverse unconjugated glycans in breast milk, act as important prebiotics and have plenty of unique health effects for growing infants. 2'-Fucosyllactose (2'-FL) is the most abundant HMO,… read more here.
Keywords: human milk; fucosyllactose abundant; production; gdp fucose ... See more keywords
GDP-L-fucose is required for boundary definition in plants
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Experimental Botany"
DOI: 10.1093/jxb/erx402
Abstract: Mutation of MURUS1 suppresses the highly serrated leaf phenotype that results from overexpression of CUP-SHAPED COTYLEDON 2 in Arabidopsis, revealing that GDP-L-fucose is involved in defining tissue boundaries during plant development. read more here.
Keywords: botany; boundary definition; definition plants; required boundary ... See more keywords