One pot synthesis of GDP‐mannose by a multi‐enzyme cascade for enzymatic assembly of lipid‐linked oligosaccharides
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26454
Abstract: Glycosylation of proteins is a key function of the biosynthetic‐secretory pathway in the endoplasmic reticulum (ER) and Golgi apparatus. Glycosylated proteins play a crucial role in cell trafficking and signaling, cell‐cell adhesion, blood‐group antigenicity, and… read more here.
Keywords: cell; lipid linked; one pot; gdp ... See more keywords
Biochemical analysis of leishmanial and human GDP-Mannose Pyrophosphorylases and selection of inhibitors as new leads
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-00848-8
Abstract: Leishmaniases are an ensemble of diseases caused by the protozoan parasite of the genus Leishmania. Current antileishmanial treatments are limited and present main issues of toxicity and drug resistance emergence. Therefore, the generation of new… read more here.
Keywords: analysis leishmanial; biochemical analysis; leishmanial human; human gdp ... See more keywords
Biochemical characterization of a GDP-mannose transporter from Chaetomium thermophilum
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1101/2023.01.13.523913
Abstract: Nucleotide Sugar Transporters (NSTs) belong to the SLC35 family (human solute carrier) of membrane transport proteins and are crucial components of the glycosylation machinery. NSTs are localized in the ER and Golgi apparatus membranes, where… read more here.
Keywords: gdp mannose; mannose transporter; chaetomium thermophilum;
GDP-Mannose 3,5-Epimerase: A View on Structure, Mechanism, and Industrial Potential
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.784142
Abstract: GDP-mannose 3,5-epimerase (GM35E, GME) belongs to the short-chain dehydrogenase/reductase (SDR) protein superfamily and catalyses the conversion of GDP-d-mannose towards GDP-l-galactose. Although the overall reaction seems relatively simple (a double epimerization), the enzyme needs to orchestrate… read more here.
Keywords: gdp mannose; mannose epimerase; industrial potential; epimerase view ... See more keywords
Molecular Evolution of GDP-D-Mannose Epimerase (GME), a Key Gene in Plant Ascorbic Acid Biosynthesis
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2018.01293
Abstract: The widespread ascorbic acid (AsA) plays a vital role in plant development and abiotic stress tolerance, but AsA concentration varies greatly among different plants. GDP-D-mannose epimerase (GME), which catalyzes GDP-D-mannose to GDP-L-galactose or GDP-L-gulose, is… read more here.
Keywords: evolution; plant; ascorbic acid; gme ... See more keywords
Impact of Hypermannosylation on the Structure and Functionality of the ER and the Golgi Complex
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11010146
Abstract: Proteins of the secretory pathway undergo glycosylation in the endoplasmic reticulum (ER) and the Golgi apparatus. Altered protein glycosylation can manifest in serious, sometimes fatal malfunctions. We recently showed that mutations in GDP-mannose pyrophosphorylase A… read more here.
Keywords: gdp mannose; gmppa; structure; golgi apparatus ... See more keywords
GDP-Mannose Pyrophosphorylase B (GMPPB)-Related Disorders
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14020372
Abstract: GDP-mannose pyrophosphorylase B (GMPPB) is a cytoplasmic protein that catalyzes the formation of GDP-mannose. Impaired GMPPB function reduces the amount of GDP-mannose available for the O-mannosylation of α-dystroglycan (α-DG) and ultimately leads to disruptions of… read more here.
Keywords: gdp mannose; pyrophosphorylase gmppb; gmppb; gmppb related ... See more keywords
Synthesis of C6-modified mannose 1-phosphates and evaluation of derived sugar nucleotides against GDP-mannose dehydrogenase
Sign Up to like & getrecommendations! Published in 2022 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.18.142
Abstract: Sufferers of cystic fibrosis are at significant risk of contracting chronic bacterial lung infections. The dominant pathogen in these cases is mucoid Pseudomonas aeruginosa. Such infections are characterised by overproduction of the exopolysaccharide alginate. We… read more here.
Keywords: gdp mannose; sugar; mannose dehydrogenase; synthesis modified ... See more keywords
AgGMP encoding GDP-D-mannose pyrophosphorylase from celery enhanced the accumulation of ascorbic acid and resistance to drought stress in Arabidopsis
Sign Up to like & getrecommendations! Published in 2022 at "PeerJ"
DOI: 10.7717/peerj.12976
Abstract: Ascorbic acid (AsA) is an important nutrient in celery, the conversion of D-mannose-1-P to GDP-D-mannose catalyzed by GDP-D-mannose pyrophosphorylase (GMPase) represents the first committed step in the biosynthesis of AsA. To clarify the function of… read more here.
Keywords: gdp mannose; ascorbic acid; drought stress; mannose pyrophosphorylase ... See more keywords