Independent Reaction Times method in Geant4-DNA: implementation and performance.
Sign Up to like & getrecommendations! Published in 2020 at "Medical physics"
DOI: 10.1002/mp.14490
Abstract: PURPOSE The simulation of individual particle tracks and the chemical stage following water radiolysis in biological tissue is an effective means of improving our knowledge of the physico-chemical contribution to the biological effect of ionizing… read more here.
Keywords: independent reaction; reaction times; implementation; geant4 dna ... See more keywords
Assessment of DNA damage with an adapted independent reaction time approach implemented in Geant4‐DNA for the simulation of diffusion‐controlled reactions between radio‐induced reactive species and a chromatin fiber
Sign Up to like & getrecommendations! Published in 2020 at "Medical Physics"
DOI: 10.1002/mp.14612
Abstract: Purpose Simulation of indirect damage originating from the attack of free radical species produced by ionizing radiation on biological molecules based on the independent pair approximation is investigated in this work. In addition, a new… read more here.
Keywords: dna; geant4 dna; time; method ... See more keywords
Monte Carlo simulations of nanodosimetry and radiolytic species production for monoenergetic proton and electron beams. Benchmarking of GEANT4-DNA and LPCHEM codes.
Sign Up to like & getrecommendations! Published in 2022 at "Medical physics"
DOI: 10.1002/mp.15609
Abstract: PURPOSE In hadrontherapy, biophysical models can be used to predict the biological effect received by cancerous tissues and organs at risk. The input data of these models generally consist of information on nano/micro dosimetric quantities… read more here.
Keywords: dna; energy; monte carlo; chemical ... See more keywords
Abstract ID: 40 Microdosimetry calculations for monoenergetic electrons using Geant4-DNA combined with a weighted track sampling algorithm
Sign Up to like & getrecommendations! Published in 2017 at "Physica Medica"
DOI: 10.1016/j.ejmp.2017.09.020
Abstract: Purpose The aim of this study was to calculate microdosimetric distributions for low energy electrons simulated using the Monte Carlo track structure code Geant4-DNA. Materials and Methods Tracks for monoenergetic electrons with kinetic energies ranging… read more here.
Keywords: electrons using; energy; dna; geant4 dna ... See more keywords
Experimental validation of an analytical microdosimetric model based on Geant4-DNA simulations by using a silicon-based microdosimeter.
Sign Up to like & getrecommendations! Published in 2020 at "Radiation physics and chemistry"
DOI: 10.1016/j.radphyschem.2020.109060
Abstract: Purpose To study the agreement between proton microdosimetric distributions measured with a silicon-based cylindrical microdosimeter and a previously published analytical microdosimetric model based on Geant4-DNA in-water Monte Carlo simulations for low energy proton beams. Methods… read more here.
Keywords: based microdosimeter; geant4 dna; silicon based;
Systematic microdosimetric data for protons of therapeutic energies calculated with Geant4-DNA.
Sign Up to like & getrecommendations! Published in 2019 at "Physics in medicine and biology"
DOI: 10.1088/1361-6560/ab47cc
Abstract: The purpose of this study was to generate physical data needed for microdosimetry-based models of proton RBE. Our focus was on the frequency and dose average lineal energies, yF and yD. We report data for… read more here.
Keywords: dna; geant4 dna; microdosimetric data; physics ... See more keywords
GEANT4-DNA simulation of temperature-dependent and pH-dependent yields of chemical radiolytic species.
Sign Up to like & getrecommendations! Published in 2023 at "Physics in medicine and biology"
DOI: 10.1088/1361-6560/acd90d
Abstract: OBJECTIVE GEANT4-DNA can simulate radiation chemical yield (G-value) for radiolytic species such as the hydrated electron (eaq-) with the Independent Reaction Times (IRT) method, however, only at room temperature and neutral pH. This work aims… read more here.
Keywords: radiolytic species; temperature dependent; geant4 dna; data within ... See more keywords
Application of Geant4-DNA for simulating water radiolysis induced by Auger electron-emitting radionuclides
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Radiation Research"
DOI: 10.1093/jrr/rrac105
Abstract: Abstract Auger-emitting radionuclides have potential application in targeted radiotherapy, particularly for metastatic cancers. This possibility, especially, is stemmed from their characteristic short-range (a few μm) in biological systems allowing localization of high dose within small… read more here.
Keywords: emitting radionuclides; geant4; geant4 dna; water ... See more keywords
Review of the Geant4-DNA Simulation Toolkit for Radiobiological Applications at the Cellular and DNA Level
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DOI: 10.3390/cancers14010035
Abstract: Simple Summary A brief description of the methodologies to simulate ionizing radiation transport in biologically relevant matter is presented. Emphasis is given to the physical, chemical, and biological models of Geant4-DNA that enable mechanistic radiobiological… read more here.
Keywords: dna; dna level; simulation; cellular dna ... See more keywords
Geant4-DNA Modeling of Water Radiolysis beyond the Microsecond: An On-Lattice Stochastic Approach
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22116023
Abstract: In this work, we use the next sub-volume method (NSM) to investigate the possibility of using the compartment-based (“on-lattice”) model to simulate water radiolysis. We, first, start with a brief description of the reaction-diffusion master… read more here.
Keywords: beyond microsecond; compartment based; geant4 dna; model ... See more keywords